Increased behavioral responses to ethanol in Lmo3 knockout mice.
Increased behavioral responses to ethanol in Lmo3 knockout mice.
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DOI：
10.1111/gbb.12176
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发表时间：
2014-11
期刊：
影响因子：
--
通讯作者：
Lasek AW
中科院分区：
文献类型：
--
作者：
Savarese A;Zou ME;Kharazia V;Maiya R;Lasek AW
LIM-domain only 3 (LMO3) is a transcriptional regulator involved in central nervous system development and neuroblastoma. Our previous studies implicated a potential role for LMO3 in regulating ethanol sensitivity and consumption. Here, we examined behavioral responses to ethanol in a line of Lmo3 null (Lmo3Z) mice, utilizing the ethanol-induced loss-of-righting-reflex (LORR) test, 2-bottle choice ethanol consumption, and the drinking in the dark (DID) test, which models binge-like ethanol consumption. We found that Lmo3Z mice exhibited increased sedation time in response to ethanol in the LORR test and drank significantly more ethanol in the DID test compared to their wild-type counterparts, but showed no differences in 2-bottle choice ethanol consumption. To explore where LMO3 may be acting in the brain to produce an ethanol phenotype, we also examined reporter gene (β-galactosidase, β-gal) expression in heterozygous Lmo3Z mice and found strong expression in subcortical areas, particularly in those areas implicated in drug abuse, including the nucleus accumbens (Acb), cortex, hippocampus, and amygdala. We also examined Lmo3 expression in the brains of wild-type mice who had undergone the DID test and found a negative correlation between Lmo3 expression in the Acb and the amount of ethanol consumed, consistent with the increased binge-like drinking observed in Lmo3Z mice. These results support a role for LMO3 in regulating behavioral responses to ethanol, potentially through its actions in the Acb.
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影响因子：
10.6
作者：
Neasta, Jeremie;Ben Hamida, Sami;Yowell, Quinn V.;Carnicella, Sebastien;Ron, Dorit
通讯作者：
Ron, Dorit
影响因子：
5.3
作者：
Friocourt G;Parnavelas JG
通讯作者：
Parnavelas JG
DOI：
10.1523/jneurosci.3415-11.2011
发表时间：
2011-10-05
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Lasek AW;Gesch J;Giorgetti F;Kharazia V;Heberlein U
通讯作者：
Heberlein U
对两项全基因组关联研究的荟萃分析，以鉴定最大含酒精饮料的新基因座。
影响因子：
5.3
作者：
Kapoor, Manav;Wang, Jen-Chyong;Wetherill, Leah;Le, Nhung;Bertelsen, Sarah;Hinrichs, Anthony L.;Budde, John;Agrawal, Arpana;Bucholz, Kathleen;Dick, Danielle;Harari, Oscar;Hesselbrock, Victor;Kramer, John;Nurnberger, John I., Jr.;Rice, John;Saccone, Nancy;Schuckit, Marc;Tischfield, Jay;Porjesz, Bernice;Edenberg, Howard J.;Bierut, Laura;Foroud, Tatiana;Goate, Alison
通讯作者：
Goate, Alison
影响因子：
3.7
作者：
Lasek AW;Lim J;Kliethermes CL;Berger KH;Joslyn G;Brush G;Xue L;Robertson M;Moore MS;Vranizan K;Morris SW;Schuckit MA;White RL;Heberlein U
通讯作者：
Heberlein U