Mortality of adults with asthma: A prospective cohort study

Mortality of adults with asthma: A prospective cohort study
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DOI：
10.1136/thx.52.1.49
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发表时间：
1997-01-01
期刊：
THORAX
影响因子：
10
通讯作者：
Koskenvuo, M
Koskenvuo, M
中科院分区：
医学1区
文献类型：
--
作者：
Huovinen, E;Kaprio, J;Koskenvuo, M

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背景-很少有关于成人哮喘患者总生存率的研究发表.进行队列研究，以评估死亡率的所有原因，慢性阻塞性肺疾病，肺癌成人asthma subjects.Methods -人口31 110芬兰成年女性和男性，大多数是双胞胎，进行了研究，比较16年的死亡率之间的哮喘（n=471）和非哮喘的人。另外293对双胞胎，不一致的哮喘，也进行了研究，以确定是否有哮喘患者的死亡率与他们的年龄匹配的兄弟姐妹不同。（年龄校正风险比男性为1.49，95%CI 1.09 - 2.05，女性为1.53，95%CI 1.10 - 2.13），哮喘受试者中慢性阻塞性肺疾病导致的死亡率也显著增加。男性哮喘患者因肺癌死亡的风险增加（吸烟校正的风险比为3.19，95% CI为1.39至7.31）。在双胞胎中发现的哮喘不一致的风险比与在整个coherent.Conclusions中发现的风险比相对应，哮喘成人的生存率比无哮喘者差。慢性阻塞性肺疾病导致的过多死亡可能部分解释了死亡率的增加，但不是全部。
Background - Few studies have been published on the overall survival of adult patients with asthma. A cohort study was performed to assess the mortality from all causes, from chronic obstructive pulmonary disease, and from lung cancer among adult asthmatic subjects.Methods - A population of 31 110 Finnish adult women and men, mostly twins, was studied to compare the 16 year mortality rates among asthmatic (n=471) and non-asthmatic persons. A further 293 twin pairs, discordant for asthma, were also studied to determine whether the mortality of patients with asthma differs from that of their age matched siblings.Results - Mortality from all causes was increased among asthmatic adults (age adjusted hazard ratios 1.49, 95% CI 1.09 to 2.05 for men and 1.53, 95% CI 1.10 to 2.13 for women), and mortality due to chronic obstructive pulmonary diseases was also significantly increased in asthmatic subjects. The risk of death due to lung cancer was increased in men with asthma (hazard ratio adjusted for smoking 3.19, 95% CI 1.39 to 7.31). The risk ratios found among twins discordant for asthma corresponded to those found in the whole cohort.Conclusions - Survival in adults with asthma is worse than in those without asthma. The excess deaths due to chronic obstructive pulmonary disease may explain some part of the increased mortality rates, but not all of it.