Fluid and protein exchange in microvascular networks: Importance of modelling heterogeneity in geometrical and biophysical properties.
Fluid and protein exchange in microvascular networks: Importance of modelling heterogeneity in geometrical and biophysical properties.
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DOI：
10.1113/jp281841
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发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
Huxley VH
中科院分区：
文献类型：
--
作者：
Guidoboni G;Marazzi NM;Fraser J;Sacco R;Palaniappan K;Huxley VH
Integration of functional results obtained across scales, from chemical signalling to the whole organism is a daunting task requiring the marriage of experimental data with mathematical modelling. In this paper a novel coupled computational fluid dynamics model is developed incorporating fluid and protein transport using measurements in an in vivo frog (Rana pipiens) mesenteric microvascular network. The influences of network architecture and exchange are explored systematically under the common assumptions of structurally and functionally identical microvessels (Homogeneous Scenario) or microvessels classified by position in flow (Class Uniform Scenario), which are compared to realistic microvascular network components (Heterogeneous Scenario). The model incorporates ten quantities that vary within a microvessel; pressure boundary conditions are calibrated against experimental measurements. The Homogeneous Scenario standard model showed that assuming a single ‘typical’ capillary hides the influence of vessels arranged into a network architecture, where capillary hydrostatic pressures (pT) are reduced resulting in both a nonuniform distribution of blood flow and reduced volume flow rate (Jf,T). In the Class Uniform Scenario pT was further attenuated to produce ≈ 60% reduction in Jf,T. Finally, the Heterogeneous Scenario, incorporating measures of individual vessel surface area, demonstrates additional lowering of pT from inlet values favoring a > 70% reduction of Jf,T in the face of a ≈ 120% increase in protein movement into the tissues relative to the Homogeneous Scenario. Beyond the impacts of network architecture, an unanticipated finding was the influence of a blind-end microvessel on model convergence, indicating a profound influence of the largely unexplored dynamics of vascular remodelling on tissue perfusion.
