Neuro-angiostrongylosis in wild Black and Grey-headed flying foxes (Pteropus spp)
Neuro-angiostrongylosis in wild Black and Grey-headed flying foxes (Pteropus spp)
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DOI：
10.1111/j.1751-0813.2002.tb11039.x
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发表时间：
2002-09-01
影响因子：
1.1
通讯作者：
Prociv, P
中科院分区：
文献类型：
--
作者：
Barrett, JL;Carlisle, MS;Prociv, P
目的通过对86只患有神经系统疾病的自由生活的狐狸进行大体和组织学检查，了解其脑组织中线虫的分布情况，并对其临床和病理特征进行描述。虫子被回收，或者如果在组织切片中看到，通过浸泡半个大脑提取，并通过显微镜检查进行鉴定。结果在86例新近提交的患有神经系统疾病的飞狐中有16例有组织学证据，1例1992年以来的病例有组织学证据。在10只狐狸中，确定其为广州管圆线虫第5期幼虫。在另外三个病例中，一条蠕虫碎片和第三期幼虫被鉴定为管圆线虫，推测为广州管圆线虫。临床表现以瘫痪为主，尤其是后肢瘫痪和抑郁，在野生动物志愿者的照顾下，飞狐存活了长达22天。含有第五期幼虫的大脑表现出中到重度的嗜酸性和肉芽肿性脑膜脑炎(n=14)，而蝙蝠的大脑几乎没有炎症，当只感染较小的第三期幼虫时死亡(n=3)。结论这是首次从澳大利亚自由生活的野生动物中回收和鉴定广州管圆线虫的报道。虽然鹰嘴病是飞行狐狸瘫痪的常见原因，但最初的临床过程无法与澳大利亚蝙蝠溶血病毒感染区分开来，野生动物护理人员应该被敦促不要试图恢复患有神经系统疾病的飞行狐狸。
Objective To identify nematodes seen in histological sections of brains of flying foxes (fruit bats) and describe the associated clinical disease and pathology.Proceedures Gross and histological examination of brains from 86 free-living flying foxes with neurological disease was done as part of an ongoing surveillance program for Australian bat lyssavirus. Worms were recovered, or if seen in histological sections, extracted by maceration of half the brain and identified by microscopic examination. Histological archives were also reviewed.Results There was histological evidence of angiostrongylosis in 16 of 86 recently submitted flying foxes with neurological disease and in one archival case from 1992. In 10 flying foxes, worms were definitively identified as Angiostrongylus cantonensis fifth-stage larvae. A worm fragment and third stage larvae were identified as Angiostrongylus sp, presumably A cantonensis, in a further three cases. The clinical picture was dominated by paresis, particularly of the hind-limbs, and depression, with flying foxes surviving up to 22 days in the care of wildlife volunteers. Brains containing fifth-stage larvae showed a moderate to severe eosinophilic and granulomatous meningoencephalitis (n = 14), whereas there was virtually no inflammation of the brains of bats which died when infected with only smaller, third-stage larvae (n = 3). There was no histological evidence of pulmonary involvement.Conclusion This is the first report of the recovery and identification of A cantonensis from free-living Australian wildlife. While anglostrongylosis is a common cause of paresis in flying foxes, the initial clinical course cannot be differentiated from Australian bat lyssavirus infection, and wildlife carers should be urged not to attempt to rehabilitate flying foxes with neurological disease.