The effects of 7-week cognitive training in patients with vascular cognitive impairment, no dementia (the Cog-VACCINE study): A randomized controlled trial
The effects of 7-week cognitive training in patients with vascular cognitive impairment, no dementia (the Cog-VACCINE study): A randomized controlled trial
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7 周认知训练对血管性认知障碍（无痴呆）患者的影响（Cog-VACCINE 研究）：一项随机对照试验
DOI：
10.1016/j.jalz.2019.01.009
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发表时间：
2019-05-01
影响因子：
14
通讯作者：
Jia, Jianping
中科院分区：
文献类型：
--
作者：
Tang, Yi;Xing, Yi;Jia, Jianping
简介：证据的认知训练在皮层下血管性认知功能障碍患者无痴呆症的疗效仍然lacking.Methods：一个随机的，积极的控制设计，使用多领域，自适应，计算机化的认知训练30分钟，5天/周，7周。评估包括整体认知功能和执行功能（主要结果）和脑功能连接和结构变化（次要结果）。在干预结束时，认知训练组在蒙特利尔认知评估中表现出相对于积极控制组的显著改善（P = .013）并显著增加左背外侧前额叶皮层和内侧前额叶皮层之间的功能连接，这与蒙特利尔认知评估变化显著相关。（P = .017）。讨论：计算机认知训练显著改善了整体认知功能，这得到了大脑可塑性改善的支持。在认知训练试验中应纳入生物标志物。(C)2019年，阿尔茨海默氏症协会。爱思唯尔公司出版All rights reserved.
Introduction: Evidence for the efficacy of cognitive training in patients with subcortical vascular cognitive impairment no dementia is still lacking.Methods: A randomized, active controlled design using multidomain, adaptive, computerized cognitive training for 30 minutes, 5 days/week for 7 weeks. Assessments included global cognitive function and executive function (primary outcomes) and brain functional connectivity and structural changes (secondary outcomes).Results: Sixty patients were randomized across three medical centers in Beijing. At the end of the intervention, the cognitive training group showed significant improvement in Montreal Cognitive Assessment relative to the active control group (P = .013) and significantly increased functional connectivity between the left dorsolateral prefrontal cortex and medial prefrontal cortex, which was significantly correlated with Montreal Cognitive Assessment change (P = .017).Discussion: Computerized cognitive training significantly improved global cognitive function, which was supported by the improved brain plasticity. Incorporation of biomarkers should be implemented in cognitive training trials. (C) 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.