Idiopathic giant-cell myocarditis - Natural history and treatment
Idiopathic giant-cell myocarditis - Natural history and treatment
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DOI：
10.1056/nejm199706263362603
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发表时间：
1997-06-26
影响因子：
158.5
通讯作者：
Shabetai, R
中科院分区：
文献类型：
--
作者：
Cooper, LT;Berry, GJ;Shabetai, R
背景：特发性巨细胞心肌炎是一种罕见且常致命的疾病。方法采用多中心资料库对63例原发性巨细胞心肌炎患者进行回顾性分析，并通过杂志报道和直接邮寄的方式，对巨细胞心肌炎的自然病程和治疗效果进行评价。88%是白色，5%是黑人，5%是东南亚或印度人，2%是中东人。大多数患者表现为充血性心力衰竭（47例患者，或75%），室性心律失常（9例患者，或14%）或心脏传导阻滞（3例患者，或5%），尽管在某些情况下，初始症状类似于急性心肌梗死（4例患者）。19%的人患有相关的自身免疫性疾病。在心肌炎治疗试验中，111例淋巴细胞性心肌炎患者的生存率更差（P
Background Idiopathic giant-cell myocarditis is a rare and frequently fatal disorder. We used a multicenter data base to define the natural history of giant-cell myocarditis and the effect of treatment,Methods We identified 63 patients with idiopathic giant-cell myocarditis through journal announcements and direct mailings to cardiovascular centers worldwide.Results The patients consisted of 33 men and 30 women with an average age of 42.6 years; 88 percent were white, 5 percent were black, 5 percent were Southeast Asian or Indian, and 2 percent were Middle Eastern. Most presented with congestive heart failure (47 patients, or 75 percent), ventricular arrhythmia (9 patients, or 14 percent), or heart block (3 patients, or 5 percent), although in some cases the initial symptoms resembled those of acute myocardial infarction (4 patients). Nineteen percent had associated autoimmune disorders. The rate of survival was worse than among 111 patients with lymphocytic myocarditis in the Myocarditis Treatment Trial (P