Secondary prevention of cervical cancer
Secondary prevention of cervical cancer
复制标题
宫颈癌二级预防
DOI：
10.1016/j.bpobgyn.2017.08.012
复制
发表时间：
2018-02-01
影响因子：
5.5
通讯作者：
Chami Kharaji, Youssef
中科院分区：
文献类型：
--
作者：
Basu, Partha;Mittal, Srabani;Chami Kharaji, Youssef
宫颈癌影响育龄妇女。筛查是一项重要的二级预防策略。从人类乳头瘤病毒(HPV)感染到浸润性癌症的漫长致癌过程为在治疗非常有效的阶段发现这种疾病提供了充足的机会。合适的筛查试验是细胞学、醋酸涂抹后的目视检查和HPV检测试验。有证据表明，这些检测方法能有效降低宫颈癌死亡率，而且筛查项目的成本效益也得到了证明。宫颈上皮内瘤变2级和3级是高级别宫颈癌的先兆，需要治疗。采用消融或切除技术治疗是安全有效的。世界卫生组织建议在30岁至49岁之间的女性一生中至少筛查一次，并确保对发现的异常情况进行有效治疗。HPV疫苗接种和基于人群的筛查相结合将有助于消除宫颈癌。(C)2018爱思唯尔有限公司。保留所有权利。
Cervical cancer affects women in their reproductive ages. Screening is an important secondary prevention strategy. The long process of carcinogenic transformation from human papillomavirus (HPV) infection to invasive cancer provides ample opportunities to detect the disease at a stage when treatment is highly effective. Suitable screening tests are cytology, visual inspection after acetic acid application and HPV detection tests. Evidence of effectiveness of the tests to reduce cervical cancer mortality and the cost-effectiveness of screening programs have been demonstrated. Cervical intraepithelial neoplasia grade 2 and grade 3 are the high-grade cervical cancer precursors and need to be treated. Treatment is safe and effective with ablative or excisional techniques. The World Health Organization recommends screening women at least once in a lifetime between 30 and 49 years of age and ensuring effective treatment of the detected abnormalities. Combination of HPV vaccination and population-based screening will be instrumental in eliminating cervical cancer. (C) 2018 Elsevier Ltd. All rights reserved.