GENTAMICIN-RESISTANT AND SILVER-RESISTANT PSEUDOMONAS IN A BURNS UNIT
GENTAMICIN-RESISTANT AND SILVER-RESISTANT PSEUDOMONAS IN A BURNS UNIT
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DOI：
10.1136/bmj.1.6161.446
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发表时间：
1979-01-01
影响因子：
--
通讯作者：
WILKINS, MD
中科院分区：
文献类型：
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作者：
BRIDGES, K;KIDSON, A;WILKINS, MD
在1977-8年，庆大霉素耐药的铜绿假单胞菌菌株在烧伤病房中变得非常普遍，在爆发高峰期超过90%具有耐药性。一些菌株也耐银硝酸盐，虽然银耐药性没有发现在任何其他菌株的铜绿假单胞菌分离。与庆大霉素抗性不同，银抗性是不稳定的，并且菌株在反复传代后变得敏感。庆大霉素耐药铜绿假单胞菌均为同一血清型（O：11，H：2，5）。虽然庆大霉素耐药性可以在体外从耐药铜绿假单胞菌转移到一种敏感的铜绿假单胞菌菌株，但没有证据表明庆大霉素耐药性在患者烧伤的假单胞菌菌株之间发生体内转移，也没有证据表明庆大霉素耐药性在铜绿假单胞菌和肠杆菌之间发生转移。羧苄青霉素耐药和庆大霉素耐药铜绿假单胞菌有时被发现在同一烧伤，但没有庆大霉素-羧苄青霉素（双重）耐药菌株中发现的986株在疫情期间进行测试。从烧伤的庆大霉素耐药铜绿假单胞菌的爆发并没有减少停止治疗与庆大霉素及其类似物，但只有通过隔离所有患者与铜绿假单胞菌的两个病房之一的单位，并承认新的患者只到其他病房。
In 1977-8 gentamicin-resistant strains of Pseudomonas aeruginosa became very common in a burns unit, over 90% being resistant at the peak of the outbreak. Some strains were also resistant to silver nitrate, though silver resistance was not found in any other strains of Ps aeruginosa isolated. Unlike the gentamicin resistance, the silver resistance was unstable, and strains became sensitive on repeated subculture. All the gentamicin-resistant strains of Ps aeruginosa were of the same serotype (O:11, H:2,5). Though gentamicin resistance could be transferred in vitro from resistant strains of Ps aeruginosa to one sensitive strain of Ps aeruginosa, there was no evidence of in-vivo transfer of gentamicin resistance between strains of pseudomonas in the patients' burns, nor was there evidence of transfer of gentamicin resistance between Ps aeruginosa and enterobacteria. Carbenicillin-resistant and gentamicin-resistant Ps aeruginosa were sometimes found in the same burns, but no gentamicin-carbenicillin (doubly) resistant strains were found among the 986 strains tested during the outbreak. The outbreak of gentamicin-resistant Ps aeruginosa from burns was not reduced by stopping treatment with gentamicin and its analogues but only by segregating all patients with Ps aeruginosa in one of the two wards of the unit and admitting new patients only to the other ward.