Changes in the three-dimensional microstructure of human tibial cancellous bone in early osteoarthritis
Changes in the three-dimensional microstructure of human tibial cancellous bone in early osteoarthritis
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DOI：
10.1302/0301-620x.85b6.12595
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发表时间：
2003-08-01
影响因子：
--
通讯作者：
Hvid, I
中科院分区：
文献类型：
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作者：
Ding, M;Odgaard, A;Hvid, I
我们从10例早期骨关节炎（OA）患者和10例正常年龄和性别匹配的近端胫骨中获取内侧和外侧软骨下松质骨标本。对标本进行micro-CT扫描，定量分析其三维显微结构特征，内侧OA松质骨明显增厚，呈板状，但力学性能低于正常骨。在OA骨的外侧标本中也观察到类似的显微结构变化，尽管没有软骨损伤的迹象。骨小梁厚度和密度增加，但连接性相对降低，提示早期OA的骨重建机制是填充骨小梁腔的过程。这一过程导致骨小梁从杆状逐渐变为板状，这与正常老化过程相反。OA患者软骨下松质骨的力学性能下降，这是由于结构和密度的恶化，表明骨质量差。
We obtained medial and lateral subchondral cancellous bone specimens from ten human postmortem proximal tibiae with early osteoarthritis (OA) and ten normal age- and gender-matched proximal tibiae. The specimens were scanned by micro-CT and the three-dimensional microstructural properties were quantified.Medial OA cancellous bone was significantly thicker and markedly plate-like, but lower in mechanical properties than normal bone. Similar microstructural changes were also observed for the lateral specimens from OA bone, although there had been no sign of cartilage damage. The increased trabecular thickness and density, but relatively decreased connectivity suggest a mechanism of bone remodelling in early OA as a process of filling trabecular cavities. This process leads to a progressive change of trabeculae from rod-like to plate-like, the opposite to that of normal ageing. The decreased mechanical properties of subchondral cancellous bone in OA, which are due to deterioration in architecture and density, indicate poor bone quality.