Enantioselective Epoxidation of Nonconjugated cis-Olefins by Chiral Dioxirane
Enantioselective Epoxidation of Nonconjugated cis-Olefins by Chiral Dioxirane
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DOI：
10.1021/ol901724v
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发表时间：
2009-11-19
期刊：
影响因子：
5.2
通讯作者：
Shi, Yian
中科院分区：
文献类型：
--
作者：
Burke, Christopher P.;Shi, Yian
用手性酮2对多种非共轭顺式烯烃进行了对映选择性环氧化反应，获得了高达92%ee的结果。烯烃的两个前手性面可能通过烯烃取代基和/或烯丙基氧官能团的相对疏水性立体区分。
A variety of nonconjugated cis-olefins has been enantioselectively epoxidized with chiral ketones 2, and up to 92% ee has been obtained. The two prochiral faces of an olefin are likely stereodifferentiated by the relative hydrophobicity of the olefin substituents and/or allylic oxygen functionality.