Impacts of age on plasma monoamine metabolite concentrations in a large cohort of healthy individuals
Impacts of age on plasma monoamine metabolite concentrations in a large cohort of healthy individuals
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DOI：
10.1016/j.psychres.2014.08.031
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发表时间：
2014-12-15
影响因子：
11.3
通讯作者：
Niwa, Shin-Ichi
中科院分区：
文献类型：
--
作者：
Soda, Emi;Miura, Itaru;Niwa, Shin-Ichi
测量单胺代谢物的血浆浓度是推断大脑中单胺代谢物动态的有用方法。为了阐明年龄和性别对血浆单胺代谢物水平的影响，我们使用高效液相色谱法测量了不同年龄的健康男性和女性（n=214）中高香草酸（HVA）、游离和总3-甲氧基-4-羟基苯基乙二醇（MHPG）和5-羟基吲哚乙酸（5-HIAA）的血浆水平。在所有血浆单胺代谢物中，不同年龄组之间存在显着差异，多重比较显示老年受试者的水平高于年轻受试者。此外，年龄与血浆 HVA、游离 MHPG、总 MHPG 和 5-HIAA 水平之间存在显着正相关。另一方面，单胺代谢物的血浆浓度不受性别影响，但总 MHPG 的血浆水平在男性中显着高于女性。单胺氧化酶和肾功能与年龄相关的变化可能会影响我们的结果。这项大型队列调查提供了进一步的证据，表明在将血浆单胺代谢水平视为中枢活动的反映时，要谨慎认识年龄的影响。 (c) 2014 Elsevier Ireland Ltd. 保留所有权利。
The measurement of plasma concentrations of monoamine metabolites is a useful method for inferring the dynamics of monoamine metabolites in the brain. To clarify effects of age and sex on plasma monoamine metabolites levels, we used high-performance liquid chromatography to measure plasma levels of homovanillic acid (HVA), free and total 3-methoxy-4-hydroxyphenylglycol (MHPG), and 5-hydroxyindoleacetic acid (5-HIAA) in healthy men and women of various ages (n=214). In all plasma monoamine metabolites, there were significant differences across the age groups, and multiple comparisons revealed that older subjects had higher levels than younger subjects. Moreover, significant positive correlations were found between age and plasma levels of HVA, free MHPG, total MHPG, and 5-HIAA. On the other hand, plasma concentrations of monoamine metabolites were not influenced by sex, except for total MHPG for which the plasma levels were significantly higher in men than in women. Age-related changes in monoamine oxidase and renal function might affect our results. This large cohort survey provides further evidence to be cautiously aware of age effects when regarding plasma monoamine metabolites levels as reflections of central activity. (c) 2014 Elsevier Ireland Ltd. All rights reserved.