The use of optical coherence tomography in screening and surveillance of Barrett's esophagus.
The use of optical coherence tomography in screening and surveillance of Barrett's esophagus.
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DOI：
10.1016/s1542-3565(05)00256-9
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发表时间：
2005-07-01
期刊：
影响因子：
--
通讯作者：
Nishioka, Norman S
中科院分区：
文献类型：
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作者：
Evans, John A;Nishioka, Norman S
巴雷特食管（BE）是指管状食管内存在特化肠上皮化生。最近的研究表明，在Barrett食管患者中进行内镜监测可有效预防早期食管腺癌。然而，监测内窥镜的准确性受到采样误差和成本的限制。光学相干断层扫描（OCT）是一种光学模拟超声，提供10微米分辨率和实时横截面图像的管腔胃肠道。综述了描述OCT在发育不良和BE模型中的应用的文献。三项研究检查了OCT在BE和发育不良模型中的应用。这些研究表明，目前可实现的分辨率结合Barrett粘膜的光散射特性足以辨别肠上皮化生，并可靠地检测BE患者的高度异型增生。需要进行更多的研究来验证这些发现。
Barrett's esophagus (BE) is defined as the presence of specialized intestinal metaplasia within the tubular esophagus. Recent studies suggest that performing endoscopic surveillance in patients with Barrett's esophagus is effective in preventing esophageal adenocarcinoma at an early stage. However, the accuracy of surveillance endoscopy is limited by sampling error and cost. Optical coherence tomography (OCT) is an optical analog of ultrasound, providing 10-microm resolution and real-time cross-sectional images of the luminal gastrointestinal tract. The literature describing the use of OCT in models of dysplasia and BE are reviewed. Three studies have examined the use of OCT in BE and models of dysplasia. These studies suggest that the currently achievable resolution combined with light-scattering properties of Barrett's mucosa is adequate to discern intestinal metaplasia and reliably detect high-grade dysplasia in patients with BE. Additional research to validate these findings is required.