An Adhesive Hydrogel with "Load-Sharing" Effect as Tissue Bandages for Drug and Cell Delivery.
An Adhesive Hydrogel with "Load-Sharing" Effect as Tissue Bandages for Drug and Cell Delivery.
复制标题
DOI：
10.1002/adma.202001628
复制
发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Ma M
中科院分区：
文献类型：
--
作者：
Chen J;Wang D;Wang LH;Liu W;Chiu A;Shariati K;Liu Q;Wang X;Zhong Z;Webb J;Schwartz RE;Bouklas N;Ma M
具有粘附性的水凝胶具有广泛的生物医学应用潜力。在这里，我们报告了一种新型的、本质粘合的水凝胶的设计，以及它在开发内部治疗绷带方面的应用。该设计涉及将“三氢键簇合物”(THBC)作为侧基并入水凝胶基质。THBC通过独特的“负载分担”效应和更高的结合密度，使水凝胶在玻璃、塑料、木材、聚四氟乙烯、不锈钢和生物组织等多种表面上有很强的粘附性，即使没有任何化学反应。使用粘附性水凝胶，我们开发了组织粘附性绷带，用于靶向和持续释放用于肝癌治疗的化疗纳米药物，或锚定输送胰岛，用于潜在的1型糖尿病(T1D)细胞替代治疗。绷带在体内的稳定粘合使原位肝癌小鼠模型几乎完全抑制了肿瘤，并在化学诱导的糖尿病小鼠中纠正了约1个月的糖尿病。基于一种新型粘性水凝胶的内部应用组织绷带被开发出来，用于将抗肿瘤药物直接输送到肿瘤部位或用于治疗1型糖尿病的胰岛素产生细胞。
Hydrogels with adhesive properties have potentials for numerous biomedical applications. Here we report the design of a novel, intrinsically adhesive hydrogel and its use in developing internal therapeutic bandages. The design involves incorporation of “triple hydrogen bonding clusters” (THBC) as side groups into the hydrogel matrix. The THBC through a unique “load sharing” effect and an increase in bond density resulted in strong adhesions of the hydrogel to a range of surfaces including glass, plastic, wood, PTFE, stainless steel and biological tissues even without any chemical reaction. Using the adhesive hydrogel, we developed tissue adhesive bandages for either targeted and sustained release of chemotherapeutic nano-drug for liver cancer treatment or anchored delivery of pancreatic islets for a potential type 1 diabetes (T1D) cell replacement therapy. Stable adhesion of the bandage inside the body enabled almost complete tumor suppression in an orthotopic liver cancer mouse model and ~1-month diabetes correction in chemically induced diabetic mice. Internally applied tissue bandages based on a novel adhesive hydrogel were developed for delivery of either anti-tumor drugs directly to the tumor site or insulin-producing cells to treat type 1 diabetes.
登录
查看更多内容
影响因子：
81.5
作者：
Llovet, Josep M.;Zucman-Rossi, Jessica;Gores, Gregory
通讯作者：
Gores, Gregory
影响因子：
41.2
作者：
Conde J;Oliva N;Atilano M;Song HS;Artzi N
通讯作者：
Artzi N
影响因子：
16.6
作者：
Giano, Michael C.;Ibrahim, Zuhaib;Medina, Scott H.;Sarhane, Karim A.;Christensen, Joani M.;Yamada, Yuji;Brandacher, Gerald;Schneider, Joel P.
通讯作者：
Schneider, Joel P.
DOI：
10.1073/pnas.1708806115
发表时间：
2018-01-09
影响因子：
11.1
作者：
An, Duo;Chiu, Alan;Ma, Minglin
通讯作者：
Ma, Minglin
影响因子：
56.9
作者：
Maier, Greg P.;Rapp, Michael V.;Butler, Alison
通讯作者：
Butler, Alison