Reliability of salivary cortisol assessments in cocaine dependent individuals
Reliability of salivary cortisol assessments in cocaine dependent individuals
复制标题
DOI：
10.1177/0269881106063474
复制
发表时间：
2006-09-01
影响因子：
4.1
通讯作者：
Sinha, R.
中科院分区：
文献类型：
--
作者：
Fox, H. C.;Wilker, E. H.;Sinha, R.
本研究的目的是评估唾液皮质醇作为衡量可卡因依赖者下丘脑-垂体-肾上腺(HPA)轴功能的可靠性。共采集49名滥用者的唾液和血浆样本，时间跨度为每天8个时间点，共3个测试日。无论男性还是女性，唾液和血浆皮质醇之间在3天内的所有时间点都有显著的相关性。这些中等显著的相关性表明，唾液测量是可卡因依赖者HPA轴功能的稳定、非侵入性和广泛的指标。
The aim of this study was to assess the reliability of salivary cortisol as a measure of hypothalmic-pituitary-adrenal (HPA) axis function in cocaine dependent individuals. Saliva and total plasma samples were collected from 49 abusers on 3 testing days in the morning, across eight time points per day. Significant associations between saliva and plasma cortisol were observed across all time points collapsed across 3 days in both men and women. These moderately significant correlations suggest that salivary measurements represent a stable, non-invasive and broad indicator of HPA axis functioning in cocaine dependent individuals.