Synaptic Plasticity in the Pain-Related Cingulate and Insular Cortex.
Synaptic Plasticity in the Pain-Related Cingulate and Insular Cortex.
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DOI：
10.3390/biomedicines10112745
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发表时间：
2022-10-28
期刊：
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
Cumulative animal and human studies have consistently demonstrated that two major cortical regions in the brain, namely the anterior cingulate cortex (ACC) and insular cortex (IC), play critical roles in pain perception and chronic pain. Neuronal synapses in these cortical regions of adult animals are highly plastic and can undergo long-term potentiation (LTP), a phenomenon that is also reported in brain areas for learning and memory (such as the hippocampus). Genetic and pharmacological studies show that inhibiting such cortical LTP can help to reduce behavioral sensitization caused by injury as well as injury-induced emotional changes. In this review, we will summarize recent progress related to synaptic mechanisms for different forms of cortical LTP and their possible contribution to behavioral pain and emotional changes.
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影响因子：
3.7
作者：
Brown JE;Chatterjee N;Younger J;Mackey S
通讯作者：
Mackey S
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Li, Bo
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Zhuo, M