Aquaculture of three phyla of marine invertebrates to yield bioactive metabolites: process developments and economics
Aquaculture of three phyla of marine invertebrates to yield bioactive metabolites: process developments and economics
复制标题
DOI：
10.1016/s1389-0344(03)00075-3
复制
发表时间：
2003-07-01
期刊：
影响因子：
--
通讯作者：
Mendola, D
中科院分区：
文献类型：
--
作者：
Mendola, D
来自海洋无脊椎动物的大规模、可再生的化学成分供应限制了潜在的新天然产物药物的开发。本文描述了为生产两种海洋无脊椎动物的大量生物量而设计和设计的两种海洋水产养殖系统的开发，这两种海洋无脊椎动物的天然产品化学成分是必需的。这两种无脊椎动物及其产品是：(1)广布的树状苔藓虫Bugula neritina(苔藓虫门)，其抗癌化学成分Bryostatin 1；和(2)Eteinascidia Turata(Tucicata门)，抗癌ecteinassidin 743的来源。对于第三类无脊椎动物Porifera及其代表海绵Acanthella cavernosa(因其抗寄生虫和抗感染而受欢迎)，海洋养殖系统并不支持可控环境的池塘水产养殖系统。对于苔藓动物和被囊动物，商业规模的海洋生产的预期经济效益被证明具有成本效益。这与受控环境的海绵培养池系统形成了鲜明的对比，由于海绵在培养过程中固有的缓慢生长和低天然产品产量，该系统被证明不经济。对一种从海绵中“挤奶”天然产品化学品的非破坏性方法进行了测试和描述。(C)2003 Elsevier Science B.V.保留所有权利。
Large-scale, renewable supplies of chemical constituents derived from marine invertebrates have limited development of potential new natural product drugs. This paper describes the development of two in-sea aquaculture systems designed and engineered for production of large quantities of biomass for two species of marine invertebrates desired for their natural product chemical constituents. The two invertebrates and their products were: (1) the cosmopolitan, arborescent bryozoan Bugula neritina (Phylum Bryozoa) for its anticancer chemical constituent bryostatin 1; and (2) Ecteinascidia turbinate (Phylum Tunicata) the source of anticancer ecteinascidin 743. For the third invertebrate Phylum Porifera, and its representative sponge Acanthella cavernosa (desired for its anti-parasitic and anti-infective kalihinols) in-sea systems were not developed in favor of controlled environment tank aquaculture systems. For the bryozoan and tunicate, projected economics for commercial-scale in-sea production proved cost effective. This was in contrast to the controlled environment sponge culture tank system, which did not prove to be economical due to inherent slow growth and low natural product yields of the sponge in culture. A non-destructive method for "milking" natural product chemicals from sponges was tested and is described. (C) 2003 Elsevier Science B.V. All rights reserved.