COLLAGEN CONTENT AND TYPES IN THE INTESTINAL STRICTURES OF CROHNS-DISEASE
COLLAGEN CONTENT AND TYPES IN THE INTESTINAL STRICTURES OF CROHNS-DISEASE
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DOI：
10.1016/0016-5085(88)90411-8
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发表时间：
1988-02-01
期刊：
影响因子：
29.4
通讯作者：
GAY, R
中科院分区：
文献类型：
--
作者：
GRAHAM, MF;DIEGELMANN, RF;GAY, R
胶原含量和胶原类型的相对量在对照肠中以及在从克罗恩病患者切除的发炎和狭窄的肠中进行定量。对照肠中主要胶原类型为I型（68%），其次为III型（20%）和V型（12%）。在狭窄肠胶原含量和V型胶原的相对量显着增加与对照组相比。组织学研究表明，在狭窄标本中，粘膜肌层平滑肌细胞显著增生，并伴有粘膜下层胶原蛋白积聚。固有肌层厚度也增加。免疫组化研究表明，少量的V型胶原蛋白在粘膜下层的控制肠。与此相反，大量的V型胶原蛋白被认为是在纤维化扩张的粘膜下层狭窄的肠，特别是在该地区的平滑肌细胞增生的粘膜肌。因此，克罗恩病中的肠狭窄的特征在于胶原蛋白的积累、平滑肌细胞的增殖和V型胶原蛋白的增加，V型胶原蛋白是由平滑肌细胞相对大量产生的胶原蛋白类型。这些变化似乎导致肠道正常顺应性的丧失和肠壁增厚，最终导致克罗恩病患者常见的肠梗阻。
The collagen content and the relative amount of collagen types were quantitated in control intestine as well as in both inflamed and strictured intestine resected from patients with Crohn''s disease. The major collagen type in control intestine was type I (68%), followed by types III (20%) and V (12%). In strictured intestine both collagen content and the relative amount of type V collagen were significantly increased compared with control intestine. Histological studies demonstrated that in strictured specimens there was a striking proliferation of smooth muscle cells of the muscularis mucosae associated with an accumulation of collagen in the submucosa. The thickness of the muscularis propria was also increased. Immunohistochemical studies demonstrated small amounts of type V collagen in the submucosa of control bowel. In contrast, large amounts of type V collagen were seen in the fibrotic expanded submucosa of stricted bowel, particularly in the areas where smooth muscle cells of the muscularis mucosae had proliferated. Intestinal strictures in Crohn''s disease are therefore characterized by an accumulation of collagen, a proliferation of smooth muscle cells, and an increase in type V collagen,a collagen type produced in relatively large amounts by smooth muscle cells. These changes appear to result in both a loss of the normal compliance of the intestine and a thickening of the intestine wall, resulting ultimately in the intestinal obstruction so frequently seen in patients with Crohn''s disease.