Daucane sesquiterpenes from Ferula hermonis
Daucane sesquiterpenes from Ferula hermonis
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DOI：
10.1021/np049652h
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发表时间：
2005-03-01
影响因子：
5.1
通讯作者：
Moulis, C
中科院分区：
文献类型：
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作者：
Lhuillier, A;Fabre, N;Moulis, C
从阿魏（Ferulahermonis）的干燥根中得到三种新的胡萝卜烷，（1 R，4 R）-4-羟基胡萝卜-7-烯-6-酮（1）、（1-R，4 R）-4-羟基胡萝卜-7-烯-6，9-二酮（2）和（1-R，3S，8 S）-3-乙氧基-8-当归酰氧基胡萝卜-4-烯-9-酮（3），以及三种已知的倍半萜，ferutinin、teferidin和（+）-alpha-红没药醇。化合物1-3的结构经波谱学鉴定。评价了这些化合物对雌激素依赖性MCF-7细胞增殖的影响，发现化合物1和3显示出增殖活性，而化合物2显示出抗增殖作用。
The dried roots of Ferula hermonis yielded three new daucanes, (1R,4R)-4-hydroxydauca-7-ene-6-one (1), (1-R,4R)-4-hydroxydauca-7-ene-6,9-dione (2), and (1-R,3S,8S)-3-ethoxy-8-angeloyloxydauca-4-en-9-one (3), together with the three known sesquiterpenes, ferutinin, teferidin, and (+)-alpha-bisabolol. The structures of compounds 1-3 were elucidated on the basis of spectroscopic evidence. The effect of these compounds on the proliferation of estrogen-dependent MCF-7 cells was evaluated, and it was found that compounds 1 and 3 exhibited proliferative activity, whereas 2 showed an antiproliferative effect.