REGULATION OF BONE-FORMATION BY APPLIED DYNAMIC LOADS
REGULATION OF BONE-FORMATION BY APPLIED DYNAMIC LOADS
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DOI：
10.2106/00004623-198466030-00012
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发表时间：
1984-01-01
影响因子：
5.3
通讯作者：
LANYON, LE
中科院分区：
文献类型：
--
作者：
RUBIN, CT;LANYON, LE
在对可在体内施加外部负荷的功能分离禽[公鸡]骨制剂的研究中，确定了以下信息。负重的去除导致骨内、皮质内以及骨膜的大量重塑。由于这种重塑的平衡是负的，骨量下降。功能性负重可以防止骨重塑过程，否则会导致骨质疏松症。每天连续四个周期的外用负荷方案会产生生理应变大小，但应变分布的改变阻止了重塑，因此骨量没有变化。适当的动态应变方案的少量暴露或第一效应似乎足以防止负平衡重塑，负平衡重塑是导致废用性骨质疏松症的原因。相同负荷方案的36个0.5 hz周期/天也阻止了皮质内吸收，但与大量骨膜和骨膜内新骨形成有关。在6周的时间里，骨矿物质含量增加到原始值的133到143%之间。生理水平的应变施加异常应变分布可以产生成骨刺激，能够增加骨量。我们观察到的骨变化的大小和特征都没有受到从36次到1800次载荷循环次数的任何额外增加的影响。
In studies on a functionally isolated avian[rooster]bone preparation to which external loads could be applied in vivo, the following information was determined. Removal of load-bearing resulted in substantial remodeling endosteally, intracortically, and, to a lesser extent, periosteally. Since the balance of this remodeling was negative, bone mass declined. Functional load-bearing prevents a remodeling process that would otherwise lead to disuse osteoporosis. Four consecutive cycles a day of an externally applied loading regimen that engendered physiological strain magnitudes, but an altered strain distribution prevented remodeling and was thus associated with no change in bone mass. A small exposure to, or the 1st effect of, a suitable dynamic strain regimen apepars to be sufficient to prevent the negatively balanced remodeling that is responsible for disuse osteoporosis. Thirty-six 0.5-Hz cycles/day of the same load regimen also prevented intracortical resorption but was associated with substantial periosteal and endosteal new-bone formation. Over a 6-wk period, bone-mineral content increased to between 133 and 143% of the original value. Physiological levels of strain imposed with an abnormal strain distribution can produce an osteogenic stimulus that is capable of increasing bone mass. Neither the size nor the character of the bone changes that we observed were affected by any additional increase in the number of load cycles from 36 to 1800.