An immunohistochemical study on the cytogenesis of adenohypophysial cells in fetal rats.
An immunohistochemical study on the cytogenesis of adenohypophysial cells in fetal rats.
复制标题
胎鼠腺垂体细胞发生的免疫组织化学研究。
DOI：
10.1016/0012-1606(79)90226-4
复制
发表时间：
1979
影响因子：
2.7
通讯作者：
S. Daikoku
中科院分区：
文献类型：
--
作者：
Y. G. Watanabe;S. Daikoku
在胎鼠中进行了免疫组织化学研究，以确定各种类型的腺垂体细胞的分化时间和它们在发育过程中首次出现和增殖的部位。在细胞分化的第一天和第二天对每种类型的细胞进行细胞计数。细胞分化的时间和部位是各细胞类型所特有的。ACTH细胞在妊娠第15天出现在远侧部的腹侧区域，在那里它面对间充质组织。虽然TSH细胞在第16天首次仅出现在后半部分，但这种细胞类型的进一步增殖也主要发生在腺体的后中部。LH和FSH细胞分别在第17天和第19天出现;两种细胞类型显示出相似的定位，即，在前半部分，它们几乎集中在腹侧区，在后半部分，它们分布稀疏而均匀。GH细胞在第18天出现在远侧部的中心区域。催乳素细胞未能在胎儿腺垂体中观察到，即使在0-1天的新生儿中，这种类型的细胞也不是一贯可见的，尽管有时在腺体的中心区域会遇到一些细胞。在这些细胞类型中，TSH、LH和FSH细胞甚至在出生后仍然集中在它们最初出现的区域。这些意见进行了讨论，与以前报告的数据由其他研究人员。
An immunohistochemical study was undertaken in fetal rats to determine the time of differentiation of various types of adenohypophysial cells and the site where they first appear and proliferate during development. A cell count was carried out on the first and second days of cytodifferentiation in each type of cell. Both the time and the site of cytodifferentiation were peculiar to respective cell types. ACTH cells appeared on Day 15 of gestation in the ventral region of the pars distalis where it faces mesenchymal tissue. While TSH cells first appeared exclusively in the posterior half on Day 16, further proliferation of this cell type also occurred predominantly in the posterocentral portion of the gland. LH and FSH cells appeared on Days 17 and 19, respectively; both cell types showed a similar localization, i.e., they were almost concentrated in the ventral region in the anterior half and posteriorly they were distributed sparsely and homogeneously. GH cells appeared on Day 18 in the central region of the pars distalis. Prolactin cells failed to be seen in the fetal adenohypophysis, and even in newborns 0–1 days of age, this type of cell was not consistently seen, although sometimes a few cells were encountered in the central region of the gland. Of these cell types, TSH, LH, and FSH cells persisted to be concentrated even after birth in the area where they first appeared. These observations are discussed in relation to data previously reported by other investigators.