Mixed phenotype acute leukemia: outcomes with allogeneic stem cell transplantation. A retrospective study from the Acute Leukemia Working Party of the EBMT.
Mixed phenotype acute leukemia: outcomes with allogeneic stem cell transplantation. A retrospective study from the Acute Leukemia Working Party of the EBMT.
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DOI：
10.3324/haematol.2017.174441
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发表时间：
2017-12
期刊：
影响因子：
10.1
通讯作者：
Nagler A
中科院分区：
文献类型：
--
作者：
Munker R;Labopin M;Esteve J;Schmid C;Mohty M;Nagler A
混合型急性白血病是罕见的，被认为是高风险。最佳的治疗方法和异基因造血干细胞移植的作用还不完全清楚。在这项研究中，我们调查了2000年至2014年期间接受异基因造血干细胞移植的519例首次完全缓解的混合表型急性白血病患者，并向欧洲血液和骨髓移植协会（EBMT）急性白血病工作组报告。中位年龄为38.1岁（范围18-75岁）。细胞遗传学分类49.3%为低风险。3年时，复发率为31.4%（26.9-35.9），非复发死亡率为22.1%（18.4-26.1），无白血病生存率为46.5%（41.7-51.4），总生存率为56.3%（51.5-61.2）。在6个月时，32.5%发生急性移植物抗宿主病，而在3年时，37.5%发生慢性移植物抗宿主病（32.6-42.3）。在多变量分析中，年龄和移植年份对结果有很大影响。使用全身照射的清髓性预处理与更好的无白血病生存率相关。我们的研究表明，混合表型急性白血病对移植物抗白血病可能敏感，因此异基因造血干细胞移植具有治愈的潜力。
Mixed phenotype acute leukemias are infrequent and considered high risk. The optimal treatment approach and the role of allogeneic hematopoietic stem cell transplantation are not entirely clear. In this study, we investigated 519 patients with mixed phenotype acute leukemia in first complete remission who underwent allogeneic hematopoietic stem cell transplantation between 2000 and 2014, and who were reported to the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT). Median age was 38.1 years (range 18–75). Cytogenetics classified 49.3% as poor risk. At three years, relapse incidence was 31.4% (26.9–35.9), non-relapse mortality was 22.1% (18.4–26.1), the leukemia-free survival was 46.5% (41.7–51.4), and the overall survival was 56.3% (51.5–61.2). At six months, 32.5% had developed acute graft-versus-host disease, while at three years, 37.5% had developed chronic graft-versus-host disease (32.6–42.3). In a multivariate analysis, age and year of transplant had a strong impact on outcome. Myeloablative conditioning using total body irradiation correlated with a better leukemia-free survival. Our study suggests that mixed phenotype acute leukemia is potentially sensitive to graft-versus-leukemia and thus can benefit from allogeneic hematopoietic stem cell transplantation with a potential for cure.
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DOI：
10.1182/asheducation-2015.1.225
发表时间：
2015-12-01
影响因子：
3
作者：
Negrin, Robert S.
通讯作者：
Negrin, Robert S.
影响因子：
4.3
作者：
Bacigalupo, Andrea;Ballen, Karen;Rizzo, Doug;Giralt, Sergio;Lazarus, Hillard;Ho, Vincent;Apperley, Jane;Slavin, Shimon;Pasquini, Marcelo;Sandmaier, Brenda M.;Barrett, John;Blaise, Didier;Lowski, Robert;Horowitz, Mary
通讯作者：
Horowitz, Mary
影响因子：
11.4
作者：
Stern, M.;de Wreede, L. C.;Ruutu, T.
通讯作者：
Ruutu, T.
影响因子：
2.7
作者：
Tian, Hong;Xu, Yang;Wu, Depei
通讯作者：
Wu, Depei
影响因子：
45.3
作者：
Freireich, Emil J.;Wiernik, Peter H.;Steensma, David P.
通讯作者：
Steensma, David P.