Neuropsychological correlates of the P300 in patients with Alzheimer's disease
Neuropsychological correlates of the P300 in patients with Alzheimer's disease
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DOI：
10.1016/j.pnpbp.2012.08.009
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发表时间：
2013-01-10
影响因子：
5.6
通讯作者：
Jung, In-Kwa
中科院分区：
文献类型：
--
作者：
Lee, Moon-Soo;Lee, Seung-Hwan;Jung, In-Kwa
目的：P300是反映认知功能的一项有用的心理生理指标，但P300与阿尔茨海默病(AD)患者神经心理测试的关系尚不清楚。两组患者的年龄和文化程度相匹配。结果：与正常对照组相比，AD患者P300波幅显著降低，但P300潜伏期差异无统计学意义。在对多项测试进行基于排列的校正后，AD患者Cz和Pz电极的P300波幅与词表识别、结构练习和词汇流畅性神经心理测试的成绩显著相关。此外，PZ和C6电极的P300潜伏期也与AD患者的简易智力状态检查、CERAD-K版(MMSE-K)和连线测验A部分(TMT-A)的表现显著相关。结论：P300潜伏期与AD患者的语言、记忆和执行功能的恶化有关。虽然AD患者的P300潜伏期与正常对照组之间没有显著差异，但P300潜伏期已被证明反映了与AD相关的整体认知和注意力缺陷。我们的结果提示，P300指数可以作为反映AD患者神经心理功能受损的生物学指标。(C)2012 Elsevier Inc.保留所有权利。
Objectives: The P300 is a useful psychophysiological index that reflects cognitive functions; however, the relationship between P300 indices and neuropsychological tests in Alzheimer's disease (AD) patients is unclear.Methods: Thirty-one AD patients and 31 elderly normal control (NC) subjects were recruited. Age and education level were matched between the two groups. The relationship between the P300 and the Korean version of the Consortium to Establish a Registry for Alzheimer's disease (CERAD-K) assessment packet (including 11 neuropsychological tests) was examined in AD patients.Results: Compared to the NC subjects, the AD patients exhibited significantly decreased P300 amplitudes; however, there was no significant difference between the two groups in terms of P300 latency. After a permutation-based correction for multiple tests, P300 amplitudes at the Cz and Pz electrodes were significantly correlated with performance on the word list recognition, constructional praxis, and word fluency neuropsychological tests in the AD patients. Additionally, P300 latencies at the Pz and C6 electrodes were also significantly correlated with performance on the Mini-Mental State Examination, CERAD-K version (MMSE-K), and Trail Making Test part A (TMT-A) neuropsychological tests in the AD patients.Conclusions: The results suggest that the P300 is responsive to the deterioration of language, memory, and executive functions observed in AD patients. Although there was no significant difference between the AD patients and NC subjects in the P300 latency, P300 latency has been shown to reflect impaired global cognition and attention deficits associated with AD. Our results suggest that P300 indices could be used as biological markers that indicate impaired neuropsychological functions in AD patients. (c) 2012 Elsevier Inc. All rights reserved.