Regional brain atrophy in children with multiple sclerosis
Regional brain atrophy in children with multiple sclerosis
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DOI：
10.1016/j.neuroimage.2011.03.025
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发表时间：
2011-09-15
期刊：
影响因子：
5.7
通讯作者：
Collins, D. L.
中科院分区：
文献类型：
--
作者：
Aubert-Broche, B.;Fonov, V.;Collins, D. L.
我们使用基于横截面张量的形态测量术来观察多发性硬化症儿童患者与健康对照组相比全脑体积的缩小。作为局部体积差异的标记，我们使用变形场的雅可比行列式将每个主体映射到标准空间。为了正确评估这一年龄组脑容量的异常差异，有必要考虑正常的、与年龄相关的脑容量差异。这是通过计算每个体素的归一化z-score雅可比行列式值来实现的，以表示个体受试者与年龄和性别匹配的健康正常人群之间的局部体积差异（标准差）。与健康对照相比，多发性硬化症患儿的丘脑和胼胝体脾的体积显著减少，脑室的体积显著扩大。t2加权病变体积与脾脏体积缩小相关，而t2加权病变体积与丘脑体积缩小无相关性。视神经通路（包括视神经束和视神经辐射）体积的减少与疾病持续时间相关。我们的研究结果表明，局灶性炎症病变可能在包括跨突触变性在内的束变性中起重要作用。爱思唯尔公司版权所有版权所有。
We used cross-sectional tensor-based morphometry to visualize reduced volume in the whole brains of pediatric patients with multiple sclerosis, relative to healthy controls. As a marker of local volume difference, we used the Jacobian determinant of the deformation field that maps each subject to a standard space. To properly assess abnormal differences in volume in this age group, it is necessary to account for the normal, age-related differences in brain volume. This was accomplished by computing normalized z-score Jacobian determinant values at each voxel to represent the local volume difference (in standard deviations) between an individual subject and an age- and sex-matched healthy normal population. Compared with healthy controls, pediatric patients with multiple sclerosis exhibited significantly reduced volumes within the thalamus and the splenium of the corpus callosum and significant expansions in the ventricles. While T2-weighted lesion volume was correlated with reduced splenium volume, no correlation was found between T2-weighted lesion volume and reduced thalamic volume. Reduced volumes of the optic pathways, including that of the optic tracts and optic radiations, correlated with disease duration. Our results suggest that focal inflammatory lesions may play an important role in tract degeneration, including transsynaptic degeneration. Crown Copyright (C) 2011 Published by Elsevier Inc. All rights reserved.