Sex-specific temporal trends in the incidence and prevalence of cardiovascular disease in young adults: a population-based study using UK primary care data.
Sex-specific temporal trends in the incidence and prevalence of cardiovascular disease in young adults: a population-based study using UK primary care data.
复制标题
年轻人心血管疾病发病率和患病率的性别特异性时间趋势：一项使用英国初级保健数据的基于人群的研究。
DOI：
10.1093/eurjpc/zwac024
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发表时间：
2022
影响因子：
8.3
通讯作者：
Okoth K
中科院分区：
文献类型：
--
作者：
Okoth K
人们担心年轻人的心血管疾病（CVD）正在上升。然而，英国目前的趋势是未知的。我们调查了性别特异性的趋势，在年轻的英国adultes.Methods和resultsA系列的年度（1998-2017年）队列和横断面研究的发病率和患病率在男性和女性16-50岁进行估计。拟合联合点回归模型以评估趋势变化。从1998年到2017年，缺血性心脏病（IHD）和心绞痛的发病率和患病率总体呈下降趋势，而冠状动脉血运重建、卒中/短暂性脑缺血发作（TIA）和心力衰竭（HF）在两种性别中均呈上升趋势。男性心肌梗死（MI）趋势稳定，女性增加。对于发病率，男性与女性的平均年百分比变化（AAPC）分别为IHD −2.6%与−3.4%;心绞痛−7.0%与−7.3%; MI 0.01%与2.3%;血运重建1.1%与3.9%;卒中/TIA 1.9%与0.6%; HF 5.6%与5.0%（除男性MI和血运重建以及女性中风/TIA外，所有趋势的P <0.05）。对于患病率，男性与女性的AAPC分别为IHD −2.8% vs. −4.9%;心绞痛−7.2% vs. −7.8%; MI −0.2% vs. 2.0;血运重建3.2% vs. 4.1%;卒中/TIA 3.1% vs. 3.6%; HF 5.0% vs. 3.0%（除男性MI外，所有趋势P <0.05）。近年来，IHD和血运重建的趋势趋于平稳，而中风/TIA和HF的趋势增加，在两个sexuals.ConclusionOverall的趋势，心血管疾病的发病率和患病率正在恶化的年轻人。需要对不利趋势背后的因素进行调查和公共卫生干预。
AimsThere is concern that cardiovascular disease (CVD) in young adults is rising. However, current trends in the UK are unknown. We investigated sex-specific trends in the incidence and prevalence of CVD in young UK adults.Methods and resultsA series of annual (1998–2017) cohort and cross-sectional studies were conducted to estimate incidence rates and prevalence in men and women aged 16–50. Joinpoint regression models were fitted to evaluate changes in trends. From 1998 to 2017, incidence and prevalence had an overall downward trend for ischaemic heart disease (IHD) and angina, while coronary revascularization, stroke/transient ischaemic attack (TIA), and heart failure (HF) had an upward trend in both sexes. Myocardial infarction (MI) trends were stable in men and increased in women. For incidence, the average annual percentage change (AAPC) for men vs. women, respectively, was IHD −2.6% vs. −3.4%; angina −7.0% vs. −7.3%; MI 0.01% vs. 2.3%; revascularization 1.1% vs. 3.9%; stroke/TIA 1.9% vs. 0.6%; HF 5.6% vs. 5.0% (Pfor trend <0.05 for all except MI and revascularization in men and stroke/TIA in women). For prevalence, AAPCs for men vs. women, respectively, were IHD −2.8% vs. −4.9%; angina −7.2% vs. −7.8%; MI −0.2% vs. 2.0; revascularization 3.2% vs. 4.1%; stroke/TIA 3.1% vs. 3.6%; HF 5.0% vs. 3.0% (Pfor trend <0.05 for all except MI in men). In recent years, IHD and revascularization trends levelled off, while stroke/TIA and HF trends increased in both sexes.ConclusionOverall trends in incidence and prevalence of CVD are worsening in young adults. Factors behind unfavourable trends warrant investigation and public health intervention.