The IGF system and breast cancer.
The IGF system and breast cancer.
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DOI：
10.1007/978-1-4614-0598-6_4
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发表时间：
2001-09
影响因子：
3.9
通讯作者：
M. Becker;D. Yee
中科院分区：
文献类型：
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作者：
M. Becker;D. Yee
The insulin-like growth factor (IGF) pathway stimulates tumorigenesis and growth in breast cancer cells and can play a pivotal role in malignant progression. As a result, clinical efforts to target IGF action, namely via receptor-based strategies, are currently underway. While IGF-targeted therapies have shown activity in early clinical trials, benefits are seen in only a minority of patients suggesting that IGF pathway markers beyond the type I IGF receptor (IGF-1R) alone may improve patient stratification. This overview evaluates multiple facets of IGF pathway contribution in breast tumors and examines both current and future obstacles facing the clinical advancement of IGF-targeted therapeutics.
