The role of homeobox genes in vascular remodeling and angiogenesis
The role of homeobox genes in vascular remodeling and angiogenesis
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DOI：
10.1161/01.res.87.10.865
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发表时间：
2000-11-10
影响因子：
20.1
通讯作者：
Walsh, K
中科院分区：
文献类型：
--
作者：
Gorski, DH;Walsh, K
含有同源结构域的转录因子在细胞增殖、分化和迁移的调控中起关键作用，并且它们在胚胎发生期间的器官发生和模式形成中起重要作用。有证据表明，其中一些是致癌基因或肿瘤抑制因子。心血管系统在胚胎发育和疾病状态如动脉粥样硬化和肿瘤诱导的血管生成过程中经历广泛的重塑，同源异型盒基因可能在调节这些过程中发挥重要作用。最近，同源异型盒基因已被检测到在血管平滑肌细胞和内皮细胞中，并且它们与病理过程如球囊血管成形术后的动脉再狭窄和肿瘤诱导的血管生成有关。其中一些基因的细胞功能开始被阐明。因此，我们简要地回顾了目前已知的同源框转录因子参与生理和病理血管重塑和血管生成。
Homeodomain-containing transcription factors are critical in the regulation of cell proliferation, differentiation, and migration, and they play an important role in organogenesis and pattern formation during embryogenesis. There is evidence that some of them are oncogenes or tumor suppressors. The cardiovascular system undergoes extensive remodeling during embryogenesis and disease states such as atherosclerosis and tumor-induced angiogenesis, and homeobox genes may play an important role in regulating these processes. Recently, homeobox genes have been detected in both vascular smooth muscle acid endothelial cells, and they are implicated in pathological processes such as arterial restenosis after balloon angioplasty and tumor-induced angiogenesis. The cellular function of some of these genes is beginning to be elucidated. Therefore, we briefly review what is currently known about the involvement of homeobox transcription factors in both physiological and pathological vascular remodeling and angiogenesis.