Epigallocatechin-3-gallate (EGCG) enhances the therapeutic activity of a dental adhesive
Epigallocatechin-3-gallate (EGCG) enhances the therapeutic activity of a dental adhesive
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表没食子儿茶素-3-没食子酸酯 (EGCG) 增强牙科粘合剂的治疗活性
DOI：
10.1016/j.jdent.2012.02.013
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发表时间：
2012-06-01
影响因子：
4.4
通讯作者：
Zhang, Yufeng
中科院分区：
文献类型：
--
作者：
Du, Xijin;Huang, Xueqing;Zhang, Yufeng
目的：本研究的目的是评估掺入不同浓度表没食子儿茶素-3-没食子酸酯（EGCG）的牙科粘合剂随时间的抗菌潜力和理化特性。方法：将 EGCG 以 100、200 和 300 μg/ml 的比例掺入牙科粘合剂中。分别通过立即或一个月后的直接接触测试和扫描电子显微镜（SEM）测定固化粘合剂对变形链球菌生长的影响。采用微拉伸粘合强度（μ TBS）测试来测试粘合剂立即或六个月后的机械性能。通过傅里叶变换红外光谱（FTIR）评估粘合剂的转化度（DC）。结果：与阴性对照相比，添加200μg/ml和300μg/ml EGCG的牙科粘合剂对变形链球菌的生长表现出抑制作用。掺有 EGCG 的牙科粘合剂的 mu TBS 高于对照。粘合剂系统的DC不受EGCG添加的影响。结论：掺入200μg/ml EGCG的牙科粘合剂可以实现发挥抗菌功能的治疗目标，同时保持树脂-牙本质粘合的耐久性。 (C) 2012 Elsevier Ltd. 保留所有权利。
Objectives: The purpose of this study was to evaluate the antibacterial potential and physicochemical properties of a dental adhesive incorporated with epigallocatechin-3-gallate (EGCG) in different concentration over time.Methods: EGCG was incorporated at a ratio of 100, 200, and 300 mu g/ml into a dental adhesive. The effects of the cured adhesives on the growth of Streptococcus mutans were determined by direct contact test immediately or one month later and by scanning electron microscopy (SEM), respectively. Microtensile bond strength (mu TBS) test was used to test the mechanical property of the adhesives immediately or six months later. The degree of conversion (DC) of the adhesives was evaluated by Fourier Transform Infrared Spectroscopy (FTIR).Results: Compared with negative control, the 200 mu g/ml and 300 mu g/ml EGCG-incorporated dental adhesive were found to exhibit inhibitory effect on the growth of S. mutans. The mu TBS of the EGCG-incorporated dental adhesive was higher than the control. The DC of the adhesive system was not affected by the addition of EGCG.Conclusions: 200 mu g/ml EGCG incorporated dental adhesives could accomplish therapeutic goals that play in antimicrobial function whilst keeping the durability of resin-dentine bond. (C) 2012 Elsevier Ltd. All rights reserved.