A common framework for EMT and collective cell migration
A common framework for EMT and collective cell migration
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DOI：
10.1242/dev.139071
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发表时间：
2016-12-01
期刊：
影响因子：
4.6
通讯作者：
Casanova, Jordi
中科院分区：
文献类型：
--
作者：
Campbell, Kyra;Casanova, Jordi
在发育过程中，细胞经常在静态和迁移行为之间切换。这种转变是发育过程中的基本事件，并与病理上的有害后果有关。长期以来，人们一直认为上皮细胞要么作为上皮细胞集体迁移，要么经历上皮细胞向间充质细胞的转变，并作为单个间充质细胞迁移。在这里，我们评估了目前已知的体内细胞迁移现象，并假设这种迁移行为不适合替代和相互排斥的类别。相反，我们认为这些类别可以被视为形态多样性的一般连续体的最极端情况，细胞具有不同程度的上皮和间充质特征或组合，并表现出一系列迁移行为。
During development, cells often switch between static and migratory behaviours. Such transitions are fundamental events in development and are linked to harmful consequences in pathology. It has long been considered that epithelial cells either migrate collectively as epithelial cells, or undergo an epithelial-to-mesenchymal transition and migrate as individual mesenchymal cells. Here, we assess what is currently known about in vivo cell migratory phenomena and hypothesise that such migratory behaviours do not fit into alternative and mutually exclusive categories. Rather, we propose that these categories can be viewed as the most extreme cases of a general continuum of morphological variety, with cells harbouring different degrees or combinations of epithelial and mesenchymal features and displaying an array of migratory behaviours.