Task-Dependent Presynaptic Inhibition
Task-Dependent Presynaptic Inhibition
复制标题
任务依赖性突触前抑制
DOI：
10.1523/jneurosci.23-05-01886.2003
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
J. Gossard
中科院分区：
文献类型：
--
作者：
Marie;J. Gossard
这项研究比较了猫两种节律性运动（运动和抓挠）期间的突触前抑制水平。切掉 L6、L7 或 S1 节段的背根，并在去大脑猫自发发生的虚构运动期间以及在 C1 和 C2 节段上应用 byd-管箭毒碱诱导的虚构抓痕期间记录其近端残根。与休息时相比，运动期间逆向尖峰的数量增加（12％），而抓挠期间大大减少（31％），并且通过刺激肌肉神经引起的背根电位（DRP）的幅度在运动期间略有减少（7％），但抓挠期间减少得更多（53％）。与运动相比，划痕过程中逆向尖峰数量的减少 (45%) 和 DRP 幅度的减少 (43%) 具有相似的幅度。此外，用微量移液管记录两只猫的轴突（n = 13）的初级传入去极化（PAD）幅度，发现与休息时相比，抓挠期间显着降低（60％）。在这两种节律期间，背根电位都存在周期性振荡，其时间与胫骨前肌节律活动的时间线性相关。与划痕相比，运动期间这些振荡的幅度明显更小（34%）。这些结果表明，划痕期间逆向活性的减少可归因于 PAD 通路中任务依赖性传输的减少，而不是与中枢模式发生器相关的潜在潜在振荡。结论是，突触前抑制和逆向放电在运动控制中可能比划痕发挥更重要的作用。
This study compares the level of presynaptic inhibition during two rhythmic movements in the cat: locomotion and scratch. Dorsal rootlets from L6, L7, or S1 segments were cut, and their proximal stumps were recorded during fictive locomotion occurring spontaneously in decerebrate cats and during fictive scratch induced byd-tubocurarine applied on the C1 and C2 segments. Compared with rest, the number of antidromic spikes was increased (by 12%) during locomotion, whereas it was greatly decreased (31%) during scratch, and the amplitude of dorsal root potentials (DRPs), evoked by stimulating a muscle nerve, was slightly decreased (7%) during locomotion but much more so during scratch (53%). When compared with locomotion, the decrease in the number of antidromic spikes (45%) and the decrease in DRP amplitude (43%) during scratch were of similar magnitude. Also, the amplitude of primary afferent depolarization (PAD), recorded with micropipettes in axons (n = 13) of two cats, was found to be significantly reduced (60%) during scratch compared with rest. During both rhythms, there were cyclic oscillations in dorsal root potential the timing of which was linearly related to the timing of rhythmic activity in tibialis anterior. The amplitude of these oscillations was significantly smaller (34%) during locomotion compared with scratch. These results suggest that the reduction in antidromic activity during scratch was attributable to a task-dependent decrease in transmission in PAD pathways and not to underlying potential oscillations related to the central pattern generator. It is concluded that presynaptic inhibition and antidromic discharge may have a more important role in the control of locomotion than scratch.
循环II：运动期间的心血管调节和适应
DOI：
--
发表时间：
2007
期刊：
Nap Limited Tokyo
影响因子：
--
作者：
Saito M;et. al.
通讯作者：
et. al.