Fatty Acid Composition of Frontal, Temporal and Parietal Neocortex in the Normal Human Brain and in Alzheimer's Disease
Fatty Acid Composition of Frontal, Temporal and Parietal Neocortex in the Normal Human Brain and in Alzheimer's Disease
复制标题
DOI：
10.1007/s11064-009-0087-5
复制
发表时间：
2010-03-01
影响因子：
4.4
通讯作者：
Love, Seth
中科院分区：
文献类型：
--
作者：
Fraser, Thomas;Tayler, Hannah;Love, Seth
饮食中的 omega 3-多不饱和脂肪酸被认为会影响阿尔茨海默病 (AD) 的风险，据报道补充二十二碳六烯酸 (DHA; 22:6n-3) 可以减少 AD 小鼠模型的神经退行性变。我们分析了 58 个正常大脑和 114 个 AD 大脑中额叶、颞叶和顶叶新皮质的脂肪酸组成。 AD 患者额叶和颞叶皮层中的硬脂酸 (18:0) 以及颞叶皮层中的花生四烯酸 (20:4n-6) 显着减少，而额叶和颞叶皮层中的油酸 (18:1n-9) 和顶叶皮层中的棕榈酸 (16:0) 则显着增加。 AD 中的 DHA 水平比对照组差异更大，但平均值没有显着差异。脂肪酸组成与APOE基因型、年龄、性别或死后延迟无关。需要进一步的研究来区分 AD 继发的改变和导致疾病过程的改变。
Dietary omega 3-polyunsaturated fatty acids are thought to influence the risk of Alzheimer's disease (AD), and supplemental docosahexaenoic acid (DHA; 22:6n-3) has been reported to reduce neurodegeneration in mouse models of AD. We have analysed the fatty acid composition of frontal, temporal and parietal neocortex in 58 normal and 114 AD brains. Significant reductions were found for stearic acid (18:0) in frontal and temporal cortex and arachidonic acid (20:4n-6) in temporal cortex in AD, and increases in oleic acid in frontal and temporal cortex (18:1n-9) and palmitic acid (16:0) in parietal cortex. DHA level varied more in AD than controls but the mean values were not significantly different. Fatty acid composition was not related to APOE genotype, age, gender or post-mortem delay. Further research is needed to distinguish between alterations that are secondary to AD and those that contribute to the disease process.