Identification of G protein-coupled receptors in the pea aphid, Acyrthosiphon pisum
Identification of G protein-coupled receptors in the pea aphid, Acyrthosiphon pisum
复制标题
豌豆蚜 Acyrthosiphon pisum 中 G 蛋白偶联受体的鉴定
DOI：
10.1016/j.ygeno.2013.06.003
复制
发表时间：
2013-10-01
期刊：
影响因子：
4.4
通讯作者：
Li, Bin
中科院分区：
文献类型：
--
作者：
Li, Chengjun;Yun, Xiaopei;Li, Bin
gpcr在生物体的生长、发育和繁殖中起着至关重要的作用。在昆虫中，已经报道了大量的全代谢虫的gpcr，但没有报道半代谢虫的gpcr。最近豌豆蚜虫基因组的测序为我们分析半代谢昆虫中gpcr的进化和潜在功能提供了机会。从典型半代谢昆虫棘球虫中鉴定出82个gpcr，其中37个具有ESTs证据，73个为首次注释。pisum， Drosophila melanogaster和Tribolium castaneum之间的一个显著差异是pisum中kinin和SIFamide受体的重复。另一个不同之处是草属植物中sulakinin受体的缺失。这些复制/丢失可能与沙棘的渗透调节、繁殖和能量代谢有关。此外，本研究将进一步促进灰蚜gpcr的功能分析，并可能为灰蚜生物防治提供新的药物靶点。(C) 2013爱思唯尔公司版权所有。
GPCRs play crucial roles in the growth, development and reproduction of organisms. In insects, a large number of GPCRs have been reported for Holometabola but not Hemimetabola. The recently sequenced pea aphid genome provides us with the opportunity to analyze the evolution and potential functions of GPCRs in Hemimetabola. 82 GPCRs were identified from the representative model hemimetabolous insect Acyrthosiphon pisum, 37 of which have ESTs evidence, and 73 are annotated for the first time. A striking difference between A. pisum, Drosophila melanogaster and Tribolium castaneum is the duplication of the kinin and SIFamide receptors in A. pisum. Another divergence is the loss of the sulfakinin receptor in A. pisum. These duplications/losses are likely involved in the osmoregulation, reproduction and energy metabolism of A. pisum. Moreover, this work will promote functional analyses of GPCRs in A. pisum and may advance new drug target discovery for biological control of the aphid. (C) 2013 Elsevier Inc. All rights reserved.