Epigenetics - Potential Contribution to Fetal Programming
Epigenetics - Potential Contribution to Fetal Programming
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DOI：
10.1007/978-1-4020-9173-5_13
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发表时间：
2009-01-01
期刊：
影响因子：
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通讯作者：
Mckay, Jill A.
中科院分区：
文献类型：
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作者：
Mathers, John C.;Mckay, Jill A.
虽然初级DNA序列设定了潜在基因表达的极限，但在特定环境下，特定细胞中的基因表达模式是由几个因素决定的，包括基因组的表观遗传标记。这些标记包括DNA甲基化和组蛋白的翻译后修饰，当DNA包装在细胞核中时，DNA被包裹在组蛋白周围。重要的是，这些标记对环境暴露的反应是可塑性的，并有助于在固定基因背景下的表型可塑性。现在有了原则证明，母亲的饮食可以对表观基因组产生深远的影响，从而决定基因表达模式和整个生命过程的健康。对改变的表观遗传标记的研究将对从机制上理解营养在健康中的作用，特别是对健康的发育起源的研究具有深远的重要性。
Whilst the primary DNA sequence sets the limits of potential gene expression, the pattern of gene expression in it given cell under particular circumstances is determined by several factors including the epigenetic marking of the genome. These marks include DNA methylation and post-translational modification of the histones around which DNA is wrapped when packaged in the nucleus. Importantly, these marks are malleable in response to environmental exposures and contribute to phenotypic plasticity in the context of a fixed genotype. There is now proof of principle that maternal diet can have a profound impact on the epigenome and so determine gene expression patterns and health throughout the life-course. Studies of altered epigenetic marking will be of profound importance for mechanistic understanding of the role of nutrition in health but especially for studies of the developmental origins of health.