Injectable in situ cross-linking hyaluronic acid/carboxymethyl cellulose based hydrogels for drug release
Injectable in situ cross-linking hyaluronic acid/carboxymethyl cellulose based hydrogels for drug release
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DOI：
10.1080/09205063.2018.1481005
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发表时间：
2018-01-01
影响因子：
3.6
通讯作者：
Ye, Xu
中科院分区：
文献类型：
--
作者：
Deng, Shuang;Li, Xian;Ye, Xu
采用溶解氧氧化二硫键法制备了一系列可注射的原位交联透明质酸/羧甲基纤维素水凝胶（HA/CMC）。结果表明，HA/CMC水凝胶具有胶凝时间可调、流变特性适宜、溶胀率高、稳定性好、药物缓释能力强等特点。HA/CMC水凝胶的胶凝时间为1.4 ~ 7.0 min， HA3/CMC3水凝胶的储存模量、复合剪切模量、动态粘度和屈服应力分别为5869 Pa、5870 Pa和587 Pa。年，和1969年，分别。培养42天后，HA1/CMC1、HA2/CMC2和HA3/CMC3水凝胶的降解率分别为60%、49%和41%；培养30天后，HA1/CMC1、HA2/CMC2和HA3/CMC3载药水凝胶的体外累积释放率分别为99%、91%和82%。该系列可注射原位交联HA/CMC水凝胶综合性能良好，在中短期药物控释、细胞包封、再生医学、组织工程等领域具有潜在的应用前景。
A series of injectable in situ cross-linking hyaluronic acid/carboxymethyl cellulose based hydrogels (HA/CMC) was prepared via disulfide bonds by the oxidation of dissolved oxygen. The results showed that HA/CMC hydrogels exhibited tunable gelling time, appropriate rheology properties, high swelling ratio, good stability, and sustained drug release ability. The gelling time of HA/CMC hydrogels ranged from 1.4 to 7.0 min, and the values of the storage modulus, complex shear modulus, dynamic viscosity, and yield stress of HA3/CMC3 hydrogel were about 5869 Pa, 5870 Pa, 587 Pa.s, and 1969 Pa, respectively. The degradation percentage of HA1/CMC1, HA2/CMC2, and HA3/CMC3 hydrogels were about 60, 49, and 41% after incubating 42 days, and the in vitro cumulative release percentage of BSA from HA1/CMC1, HA2/CMC2, and HA3/CMC3 drug-loaded hydrogels were about 99, 91, and 82% after 30 days. The series of injectable in situ cross-linking HA/CMC hydrogels exhibited good comprehensive performance, signifying that these hydrogels could be potentially used in the fields of short-and medium-term controlled drug release, cell encapsulation, regenerative medicine, and tissue engineering.[GRAPHICS].