Corticocortical Evoked Potentials Reveal Projectors and Integrators in Human Brain Networks
Corticocortical Evoked Potentials Reveal Projectors and Integrators in Human Brain Networks
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DOI：
10.1523/jneurosci.4289-13.2014
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发表时间：
2014-07-02
影响因子：
5.3
通讯作者：
Mehta, Ashesh D.
中科院分区：
文献类型：
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作者：
Keller, Corey J.;Honey, Christopher J.;Mehta, Ashesh D.
大脑皮层由多个子区域组成，这些子区域的功能专门化很大程度上取决于它们之间的传入和传出连接。在本研究中，我们询问哪些皮质区域可以对其他区域和整个皮质网络产生最大的影响。之前关于这个问题的研究依赖于粗略的解剖学（映射大纤维路径）或功能连接（映射正在进行的活动中的区域间统计依赖性）。在这里，我们将直接电刺激与皮质表面的记录相结合，为清醒人类大脑皮层内的定向、区域间影响提供了新的见解。这些定向交互网络在不同强度阈值和不同受试者之间是可重复的。定向网络属性包括（1）连接的互易性随着距离的增加而减少； (2)在Rolandic皮质周围以及颞叶的后部、基底和极区发现了主要的投射节点（影响源）； (3) 在额叶前外侧、顶叶上和颞上区发现了主要接收器节点（影响接收器）。从电刺激和静息皮层电图 (ECoG) 相关性得出的连接图显示同一源节点的相似空间分布。然而，更高级别的网络拓扑分析揭示了电刺激和 ECoG 之间的差异，部分与连接的互易性有关。总之，这些发现帮助我们理解大规模皮质影响以及功能连接网络的解释。
The cerebral cortex is composed of subregions whose functional specialization is largely determined by their incoming and outgoing connections with each other. In the present study, we asked which cortical regions can exert the greatest influence over other regions and the cortical network as a whole. Previous research on this question has relied on coarse anatomy (mapping large fiber pathways) or functional connectivity (mapping inter-regional statistical dependencies in ongoing activity). Here we combined direct electrical stimulation with recordings from the cortical surface to provide a novel insight into directed, inter-regional influence within the cerebral cortex of awake humans. These networks of directed interaction were reproducible across strength thresholds and across subjects. Directed network properties included (1) a decrease in the reciprocity of connections with distance; (2) major projector nodes (sources of influence) were found in peri-Rolandic cortex and posterior, basal and polar regions of the temporal lobe; and (3) major receiver nodes (receivers of influence) were found in anterolateral frontal, superior parietal, and superior temporal regions. Connectivity maps derived from electrical stimulation and from resting electrocorticography (ECoG) correlations showed similar spatial distributions for the same source node. However, higher-level network topology analysis revealed differences between electrical stimulation and ECoG that were partially related to the reciprocity of connections. Together, these findings inform our understanding of large-scale corticocortical influence as well as the interpretation of functional connectivity networks.