A comparative infection study of pigeon and avian paramyxovirus type 1 viruses in pigeons: evaluation of clinical signs, virus shedding and seroconversion
A comparative infection study of pigeon and avian paramyxovirus type 1 viruses in pigeons: evaluation of clinical signs, virus shedding and seroconversion
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DOI：
10.1080/03079457.2010.542131
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发表时间：
2011-01-01
期刊：
影响因子：
2.8
通讯作者：
Peeters, B. P. H.
中科院分区：
文献类型：
--
作者：
Dortmans, J. C. F. M.;Koch, G.;Peeters, B. P. H.
研究了鸽1型副粘病毒（PPMV-1）分离株AV 324/96及其重组衍生物rgAV 324对鸽的致病性。为了进行比较，还包括强毒鸡病毒FL-Herts，其是Herts/33株的重组衍生物。通过眼内、鼻内和肠道联合途径接种后，检查临床体征、病毒脱落和血清学应答。仅在FL-Herts感染组中观察到临床体征。所有接种病毒的鸽子在感染后5天内气管拭子均呈阳性。然而，只有AV 324/96感染和rgAV 324感染的禽类，而不是FL-赫茨感染的禽类，在泄殖腔中散播病毒。AV 324/96感染的鸽子显示出比rgAV 324感染的鸟更高的平均抗体滴度，而FL-赫茨感染组的抗体滴度相当低。结果表明，鸽株AV 324对鸽没有毒性，但强调了家禽被无症状鸽散发的PPMV-1感染的潜在风险。
The pathogenesis of pigeon paramyxovirus type 1 (PPMV-1) isolate AV324/96 and of its recombinant derivative, rgAV324, was studied in pigeons. For comparison, the virulent chicken virus FL-Herts, which is a recombinant derivative of strain Herts/33, was also included. After inoculation by the combined intraocular, intranasal and intratracheal route, clinical signs, virus shedding and serological responses were examined. Clinical signs were observed only in the FL-Herts-infected group. All virus-inoculated pigeons had positive tracheal swabs until 5 days post infection. However, only the AV324/96-infected and rgAV324-infected birds, and not the FL-Herts-infected birds, shed virus in the cloaca. The AV324/96-infected pigeons showed higher mean antibody titres than the rgAV324-infected birds, whereas the antibody titres of the FL-Herts-infected group were rather low. The results show that the pigeon strain AV324 is not virulent for pigeons, but underlines the potential risk of poultry becoming infected by PPMV-1 shed by non-symptomatic pigeons.