High expression of FMNL1 protein in T non-Hodgkin's lymphomas
High expression of FMNL1 protein in T non-Hodgkin's lymphomas
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DOI：
10.1016/j.leukres.2005.10.003
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发表时间：
2006-06-01
影响因子：
2.7
通讯作者：
Saad, STO
中科院分区：
文献类型：
--
作者：
Favaro, PMB;Traina, F;Saad, STO
我们最近克隆了一个新的Formin-fan-lily人类基因，命名为人类白细胞formin，并被HUGO基因命名委员会事后命名为FMNL 1。该基因在淋巴恶性肿瘤中过表达，并与Akt相关。在这里，我们描述了FMNL 1蛋白的表达在54冷冻活检的非霍奇金淋巴瘤（NHL）患者和5个反应性淋巴结。免疫印迹分析显示FMNL 1在所有研究的样本中均有表达，但在T细胞NHL中表达最高（P < 0.05）。(c)2005爱思唯尔有限公司保留所有权利。
We recently cloned a novel Formin-fan-lily human gene, denominated human leukocyte formin and posteriorly named as FMNL1 by the HUGO Gene Nomenclature Committee. This gene is overexpressed in lymphoid malignances and is found associated with Akt. Here, we describe the expression of the FMNL1 protein in 54 frozen biopsies of non-Hodgkin's lymphoma (NHL) patients and five reactive lymph nodes. Western blot analysis revealed expression of FMNL1 in all samples studied, although the highest expression was in T-cell NHL (P < 0.05). (c) 2005 Elsevier Ltd. All rights reserved.