Ablation of the hypothalamic neuropeptide melanin concentrating hormone is associated with behavioral abnormalities that reflect impaired olfactory integration.
Ablation of the hypothalamic neuropeptide melanin concentrating hormone is associated with behavioral abnormalities that reflect impaired olfactory integration.
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DOI：
10.1016/j.bbr.2011.05.039
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发表时间：
2011-10-10
影响因子：
2.7
通讯作者：
Maratos-Flier E
中科院分区：
文献类型：
--
作者：
Adams AC;Domouzoglou EM;Chee MJ;Segal-Lieberman G;Pissios P;Maratos-Flier E
黑色素浓集激素（MCH）是一种下丘脑促食欲神经肽。至少一种受体，MCH受体1（MCHR1），存在于所有哺乳动物中，并且在整个大脑中广泛表达，包括皮质、纹状体和涉及嗅觉线索整合的结构，如梨状皮质和嗅球。与MCH在介导嗅觉功能中的潜在作用一致，MCH基因敲除小鼠表现出异常的嗅觉行为。这些行为包括两种性别的食物寻求受损，同时保持正常的运动水平，这表明嗅觉受损。男性也表现出增加的侵略性，而女性表现出缺陷的几个嗅觉介导的行为，包括交配，发情周期同步和母性行为。这些结果表明，下丘脑通过MCH的输入发挥了重要作用，在调节嗅觉通路的感觉整合。
Melanin-concentrating hormone (MCH) is an orexigenic hypothalamic neuropeptide. At least one receptor, MCH receptor 1 (MCHR1), is present in all mammals and is expressed widely throughout the brain, including cortex, striatum and structures implicated in the integration of olfactory cues such as the piriform cortex and olfactory bulb. Consistent with a potential role for MCH in mediating olfactory function, MCH knockout mice demonstrate abnormal olfactory behaviors. These behaviors include impaired food seeking by both genders while maintaining normal levels of locomotion, suggesting impaired olfaction. Males also exhibit increased aggression while females show defects in several olfactory mediated behaviors including mating, estrous cycle synchronization and maternal behavior. These findings suggest that hypothalamic inputs through MCH play an important role in regulating sensory integration from olfactory pathways.