Diffraction Enhanced Imaging of a Rat Model of Gastric Acid Aspiration Pneumonitis
Diffraction Enhanced Imaging of a Rat Model of Gastric Acid Aspiration Pneumonitis
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DOI：
10.1016/j.acra.2011.08.005
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发表时间：
2011-12-01
影响因子：
4.8
通讯作者：
Pisano, Etta D.
中科院分区：
文献类型：
--
作者：
Connor, Dean M.;Zhong, Zhong;Pisano, Etta D.
基本原理和目的：衍射增强成像(DEI)是一种位相对比X射线成像，在许多成像应用中，它以较低的剂量改善了图像对比度，但还没有研究确定DEI是否对诊断肺损伤有用。本研究的目的是确定DEI能否在大鼠胃吸入模型中区分健康肺和损伤肺，并将衍射增强图像与胸部X线片进行比较。材料和方法：成年SD大鼠分别于吸入0.4mL/kg L盐酸液前和后4h摄取胸部X线片和衍射增强图像。结果：X线片和增强衍射峰图像显示损伤大鼠肺内有肺不张的区域。与胸片相比，衍射峰增强图像显示了肺的完整范围，尤其是在横断面后延伸的下叶部分。结论：对于胃酸吸入的大鼠模型，DEI能够区分健康和受损的肺，并且比X线片更清楚地显示肺的完整范围和肺损伤。
Rationale and Objectives: Diffraction-enhanced imaging (DEI) is a type of phase contrast x-ray imaging that has improved image contrast at a lower dose than conventional radiography for many imaging applications, but no studies have been done to determine if DEI might be useful for diagnosing lung injury. The goals of this study were to determine if DEI could differentiate between healthy and injured lungs for a rat model of gastric aspiration and to compare diffraction-enhanced images with chest radiographs.Materials and Methods: Radiographs and diffraction-enhanced chest images of adult Sprague Dawley rats were obtained before and 4 hours after the aspiration of 0.4 mL/kg of 0.1 mol/L hydrochloric acid. Lung damage was confirmed with histopathology.Results: The radiographs and diffraction-enhanced peak images revealed regions of atelectasis in the injured rat lung. The diffraction-enhanced peak images revealed the full extent of the lung with improved clarity relative to the chest radiographs, especially in the portion of the lower lobe that extended behind the diaphragm on the anteroposterior projection.Conclusions: For a rat model of gastric acid aspiration, DEI is capable of distinguishing between a healthy and an injured lung and more clearly than radiography reveals the full extent of the lung and the lung damage.