HUMAN INFLUENZA RESULTING FROM AEROSOL INHALATION
HUMAN INFLUENZA RESULTING FROM AEROSOL INHALATION
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DOI：
10.3181/00379727-122-31255
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发表时间：
1966-01-01
影响因子：
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通讯作者：
KNIGHT, V
中科院分区：
文献类型：
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作者：
ALFORD, RH;KASEL, JA;KNIGHT, V
志愿者被给予A2流感病毒的小颗粒气雾剂。感染和典型的流感是由以这种方式给予的低剂量病毒引起的。低水平的血清中和抗体不能完全有效地预防感染和疾病。当通过气雾剂对不含血清中和抗体的受试者给药时，该流感毒株的人类感染剂量约为3 TCID50。
Volunteers were given A2 influenza virus in a small-particle aerosol. Infection and typical influenza resulted from low doses of virus administered in this manner. Low levels of serum neutralizing antibody were not completely effective in preventing infection and illness. The human infectious dose of this influenza strain when administered by aerosol to subjects free of serum neutralizing antibody was approximately 3 TCID50.