DOPAMINE-D1 AND D2 RECEPTOR INTERACTIONS IN THE MPTP-TREATED MARMOSET
DOPAMINE-D1 AND D2 RECEPTOR INTERACTIONS IN THE MPTP-TREATED MARMOSET
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DOI：
10.1016/0304-3940(92)90606-8
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发表时间：
1992-08-03
影响因子：
2.5
通讯作者：
CLOSE, SP
中科院分区：
文献类型：
--
作者：
ELLIOTT, PJ;WALSH, DM;CLOSE, SP
在改进的MPTP模型中，发现L-DOPA和多巴胺D2激动剂喹吡罗都表现出抗运动迟缓活性。多巴胺D1激动剂SKF 38393和D1拮抗剂SCH 23390都降低了L-DOPA和喹吡罗的抗运动迟缓作用。这些结果进行了讨论相对于SKF 38393的部分激动剂活性和其他多巴胺受体可能需要抗帕金森病药物活性的可能性。
In a modified MPTP model of Parkinson's disease in the marmoset, both L-DOPA and the dopamine D2 agonist quinpirole were found to exhibit anti-bradykinetic activity. Both the dopamine D1 agonist SKF38393 and the D1 antagonist SCH23390 reduced the anti-bradykinetic action of L-DOPA and quinpirole. These results are discussed with respect to partial agonist activity of SKF38393 and the possibility that other dopamine receptors may be required for anti-Parkinsonian drug activity.