Caveolin‐1 modulates the activity of the volume‐regulated chloride channel
Caveolin‐1 modulates the activity of the volume‐regulated chloride channel
复制标题
Caveolin-1 调节容量调节氯离子通道的活性
DOI：
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
J. Eggermont
中科院分区：
文献类型：
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作者：
D. Trouet;B. Nilius;Axel Jacobs;C. Remacle;G. Droogmans;J. Eggermont
1 Caveolae are small invaginations of the plasma membrane that have recently been implicated in signal transduction. In the present study, we have investigated whether caveolins, the principal protein of caveolae, also modulate volume‐regulated anion channels (VRACs). 2 I Cl,swell, the cell swelling‐induced chloride current through VRACs, was studied in three caveolin‐1‐deficient cell lines: Caco‐2, MCF‐7 and T47D. 3 Electrophysiological measurements showed that ICl,swell was very small in these cells and that transient expression of caveolin‐1 restored ICl,swell. The caveolin‐1 effect was isoform specific: caveolin‐1β but not caveolin‐1α upregulated VRACs. This correlated with a different subcellular distribution of caveolin‐1α (perinuclear location) from caveolin‐1β (perinuclear and peripheral). 4 To explain the modulation of ICl,swell by caveolin‐1 we propose that caveolin increases the availability of VRACs in the plasma membrane or, alternatively, that it plays a crucial role in the signal transduction cascade of VRACs.
P-糖蛋白相关的氯电流被细胞肿胀激活，但不参与细胞体积调节。
影响因子：
11.2
作者：
Altenberg,GA;Deitmer,JW;Glass,DC;Reuss,L
通讯作者：
Reuss,L