Transient Activation of Superior Prefrontal Cortex during Inhibition of Cognitive Set
Transient Activation of Superior Prefrontal Cortex during Inhibition of Cognitive Set
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DOI：
10.1523/jneurosci.23-21-07776.2003
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发表时间：
2003-08
期刊：
影响因子：
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通讯作者：
S. Konishi;K. Jimura;Tomoki Asari;Y. Miyashita
中科院分区：
文献类型：
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作者：
S. Konishi;K. Jimura;Tomoki Asari;Y. Miyashita
前额叶皮层执行设定转换功能，其中包括抑制先前获得的认知设定。抑制功能的损害导致持续的行为，形成额叶功能障碍的特征之一。先前的神经影像学研究揭示了下前额皮质的抑制机制。目前的功能磁共振成像研究在集合转换范式中设计了“双重匹配”刺激，使我们能够暂时隔离在暴露于先前获得的集合期间招募的抑制过程。在靠近额上沟的左侧额中回中发现了与孤立抑制时间锁定的瞬时激活。然而，在受试者被告知并意识到暴露后进行的对照实验中，上前额叶激活消失，并且在包括左后下额沟在内的一组大脑区域中显示出显着的激活。这些双重解离结果表明，上前额叶皮层中的抑制机制取代了下前额叶皮层的抑制机制，其激活取决于受试者抑制认知集的策略。
The prefrontal cortex implements a set-shifting function that includes inhibition of a previously acquired cognitive set. The impairment of the inhibitory function results in perseverative behavior that forms one characteristic feature of frontal lobe dysfunction. Previous neuroimaging studies have revealed inhibitory mechanisms in the inferior prefrontal cortex. The present functional magnetic resonance imaging study devised “dual-match” stimuli in a set-shifting paradigm that allowed us to temporally isolate the inhibitory processes recruited during exposure to a previously acquired set. Transient activation time-locked to the isolated inhibition was revealed in the left middle frontal gyrus near the superior frontal sulcus. In a control experiment conducted after subjects had been informed and made aware of the exposure, however, the superior prefrontal activation disappeared, and prominent activation was revealed in a set of brain regions that included the left posterior inferior frontal sulcus. These double dissociation results indicate inhibitory mechanisms in the superior prefrontal cortex, alternative to the inferior prefrontal ones, that are activated depending on the subjects' strategy for inhibition of cognitive set.