The phospholipase A2 superfamily and its group numbering system
The phospholipase A2 superfamily and its group numbering system
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DOI：
10.1016/j.bbalip.2006.07.011
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发表时间：
2006-11-01
影响因子：
4.8
通讯作者：
Dennis, Edward A.
中科院分区：
文献类型：
--
作者：
Schaloske, Ralph H.;Dennis, Edward A.
磷脂酶A（2）（PLA（2））酶的超家族目前由15个组和许多亚组组成，并且包括五种不同类型的酶，即分泌型PLA（2）s（sPLA（2））、胞质型PLA（2）s（cPLA 2）、不依赖Ca 2+的PLA（2）s（iPLA（2））、血小板活化因子乙酰水解酶（PAF-AH）和溶酶体型PLA（2）s。1994年，我们建立了这些酶系统的组编号系统。从那时起，PLA 2超家族不断增长，在其间的几年里，需要对这个组编号系统进行几次更新。自从我们上次更新以来，已经发现了一些新的PLA 2，现在包括在内。此外，还描述了研究PLA 2的工具以及区分不同群体的方法。(c)2006 Elsevier B. V.保留所有权利。
The superfamily of phospholipase A(2) (PLA(2)) enzymes currently consists of 15 Groups and many subgroups and includes five distinct types of enzymes, namely the secreted PLA(2)s (sPLA(2)) the cytosolic PLA(2)s (cPLA2), the Ca2+ independent PLA(2)s (iPLA(2)), the platelet-activating factor acetylhydrolases (PAF-AH), and the lysosomal PLA(2)s. In 1994, we established the systematic Group numbering system for these enzymes. Since then, the PLA2 superfamily has grown continuously and over the intervening years has required several updates of this Group numbering system. Since our last update, a number of new PLA2s have been discovered and are now included. Additionally, tools for the investigation of PLA2s and approaches for distinguishing between the different Groups are described. (c) 2006 Elsevier B.V. All rights reserved.