Modulation of attention networks serving reorientation in healthy aging
Modulation of attention networks serving reorientation in healthy aging
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DOI：
10.18632/aging.103515
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发表时间：
2020-07-15
期刊：
影响因子：
5.2
通讯作者：
Wilson, Tony W.
中科院分区：
文献类型：
--
作者：
Arif, Yasra;Spooner, Rachel K.;Wilson, Tony W.
引导对行为相关刺激的注意对日常功能至关重要，主要涉及额顶背侧和腹侧网络的活动。许多研究表明，随着年龄的增长，注意力重新分配的速度和准确性都会下降，但潜在的神经动力学仍然知之甚少。我们使用脑磁图(MEG)和波斯纳任务对94名健康成年人(22-72岁)的这种年龄相关性下降进行了研究。脑磁图数据在时间-频率域被检查，并使用波束形成器对显著的振荡响应进行成像。我们发现，当需要注意重新分配时，参与者的反应较慢(即有效性效应)，并且这种效应与年龄呈正相关。我们还发现，在350-950毫秒的时间内，年龄相关的效度对左侧顶叶的阿尔法活动和左侧额眼视野的贝塔活动有影响。总体而言，在注意力重新分配试验中，在较年轻的参与者中观察到了更强的阿尔法和贝塔反应，但在年龄较大的参与者中，这种模式相反。有趣的是，这种阿尔法效度效应完全中介了年龄和行为表现之间的关系。总而言之，老年人在重新调整注意力方向方面速度较慢，并在顶叶和额叶区域表现出与年龄相关的阿尔法和贝塔反应变化，这可能反映了更多的任务需求耗尽了他们的补偿资源。
Orienting attention to behaviorally relevant stimuli is essential for everyday functioning and mainly involves activity in the dorsal and ventral frontoparietal networks. Many studies have shown declines in the speed and accuracy of attentional reallocation with advancing age, but the underlying neural dynamics remain less understood. We investigated this age-related decline using magnetoencephalography (MEG) and a Posner task in 94 healthy adults (22-72 years old). MEG data were examined in the time-frequency domain, and significant oscillatory responses were imaged using a beamformer. We found that participants responded slower when attention reallocation was needed (i.e., the validity effect) and that this effect was positively correlated with age. We also found age-related validity effects on alpha activity in the left parietal and beta in the left frontal - eye fields from 350-950 ms. Overall, stronger alpha and beta responses were observed in younger participants during attention reallocation trials, but this pattern was reversed in the older participants. Interestingly, this alpha validity effect fully mediated the relationship between age and behavioral performance. In conclusion, older adults were slower in reorienting attention and exhibited age-related alterations in alpha and beta responses within parietal and frontal regions, which may reflect increased task demands depleting their compensatory resources.