Murine models for antiretroviral therapy.
Murine models for antiretroviral therapy.
复制标题
用于抗逆转录病毒治疗的小鼠模型。
DOI：
10.1159/000150118
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发表时间：
1989
期刊：
影响因子：
4.6
通讯作者：
Ruprecht,RM
中科院分区：
文献类型：
--
作者：
Ruprecht,RM
成年小鼠感染劳舍尔小鼠白血病病毒（RLV）导致脾肿大，这与病毒滴度成正比。我们使用该模型研究了慢性病毒血症的治疗以及病毒暴露后的化学预防，包括单药治疗和联合治疗。我们发现在病毒暴露后及时开始有效的抗病毒治疗可以预防新发感染。我们还开发了一种小鼠嗜神经逆转录病毒模型，可以分析候选抗病毒药物在血脑屏障中的活性。该模型还可用于研究妊娠中期或新生儿期获得的逆转录病毒感染的治疗方法。
Rauscher murine leukemia virus (RLV) infection of adult mice results in splenomegaly that is proportional to the virus titer. We have used this model to study the therapy of chronic viremia as well as chemoprophylaxis after viral exposure, both with single agents and with combination therapy. We showed that prompt initiation of effective antiviral therapy after viral exposure can prevent de novo infection. We have also developed a murine neurotropic retrovirus model which allows analysis of candidate antiviral agents for activity across the blood-brain barrier. This model can also be used to study therapeutic approaches to retroviral infections acquired at midgestation or during the neonatal period.