Stress inhibits hair growth in mice by induction of premature catagen development and deleterious perifollicular inflammatory events via neuropeptide substance P-dependent pathways
Stress inhibits hair growth in mice by induction of premature catagen development and deleterious perifollicular inflammatory events via neuropeptide substance P-dependent pathways
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DOI：
10.1016/s0002-9440(10)63877-1
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发表时间：
2003-03-01
影响因子：
6
通讯作者：
Paus, R
中科院分区：
文献类型：
--
作者：
Arck, PC;Handjiski, B;Paus, R
压力是否会以临床相关的方式导致脱发（休止期脱发）一直存在很大争议。尽管头发在人类社会中具有重要的心理社会意义，但临床应用压力研究的这个核心但神秘且有争议的问题尚未在适当的动物模型中进行系统研究。我们现在表明，心理情绪压力确实改变了实际的毛囊（HF）在体内的循环，即提前终止活跃的毛发生长（毛发生长期）在小鼠的正常持续时间。此外，在应激小鼠的HF环境中存在对HF有害的炎性事件（滤泡周围巨噬细胞簇、过度肥大细胞活化）。这提供了第一个坚实的病理生理学机制，压力如何可能实际上导致休止期脱发，即通过毛发周期操纵和神经免疫学事件，联合收割机终止生长期。此外，我们表明，大多数这些毛发生长抑制作用的压力可以复制的蛋白质型压力相关的神经肽P物质在非应激小鼠，并可以有效地抵消了共同管理的一个特定的P物质受体拮抗剂在应激小鼠。这提供了第一个令人信服的理由如何压力引起的男性脱发可能会被有效地管理。
It has been much disputed whether or not stress can cause hair loss (telogen effluvium) in a clinically relevant manner. Despite the paramount psychosocial importance of hair in human society, this central, yet enigmatic and controversial problem of clinically applied stress research has not been systematically studied in appropriate animal models. We now show that psychoemotional stress indeed alters actual hair follicle (HF) cycling in vivo, ie, prematurely terminates the normal duration of active hair growth (anagen) in mice. Further, inflammatory events deleterious to the HF are present in the HF environment of stressed mice (perifollicular macrophage cluster, excessive mast cell activation). This provides the first solid pathophysiological mechanism for how stress may actually cause telogen effluvium, ie, by hair cycle manipulation and neuroinummological events that combine to terminate anagen. Furthermore, we show that most of these hair growth-inhibitory effects of stress can be reproduced by the proteotypic stress-related neuropeptide substance P in nonstressed mice, and can be counteracted effectively by co-administration of a specific substance P receptor antagonist in stressed mice. This offers the first convincing rationale how stress-induced hair loss in men may be pharmacologically managed effectively.