Effects of Cytokines on Glucocorticoid Receptor Expression And Function
Effects of Cytokines on Glucocorticoid Receptor Expression And Function
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DOI：
10.1007/978-0-585-37970-8_7
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发表时间：
1999
影响因子：
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通讯作者：
A. Miller;C. Pariante;B. D. Pearce
中科院分区：
文献类型：
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作者：
A. Miller;C. Pariante;B. D. Pearce
大量数据令人信服地证明免疫系统和神经系统广泛地相互作用（Ader, Cohen, & Felten, 1991; Miller, In Press）。免疫细胞和组织表达与神经系统相关并受神经系统调节的多种递质受体，包括神经递质、多肽和激素，淋巴组织的神经系统支配已被很好地表征。此外，在多种神经系统和内分泌组织中发现了可溶性免疫产物（细胞因子）及其受体的存在（besdovsky & del Rey, 1996）。暴露于各种压力源导致的神经系统功能改变已被证明会导致免疫系统功能的剧烈变化，并且暴露于细胞因子或各种类型的免疫激活已被证明会显著改变中枢神经系统功能（Miller, in Press; McEwen, Biron, Brunson, Bulloch, Chambers, Dhabhar, Goldfarb, Kitson, Miller, Spencer, & Weiss, 1997; Kent, Bluthe, Kelley, & Dantzer, 1992）。鉴于涉及免疫系统和大脑的相互调节的巨大潜力，免疫系统过程可能参与包括重度抑郁症在内的精神综合征的病理生理的可能性引起了相当大的兴趣。一种可能的机制是，免疫系统可能促进病理发展，表现为抑郁症状，涉及细胞因子抑制糖皮质激素受体功能的能力，从而诱导糖皮质激素抵抗状态。
A large body of data has been amassed which convincingly demonstrates that the immune system and the nervous system extensively interact (Ader, Cohen, & Felten, 1991; Miller, In Press). Immune cells and tissues express receptors for a wide range of transmitters associated with and regulated by the nervous system including neuro-transmitters, peptides and hormones, and nervous system innervation of lymphoid tissues has been well characterized. Moreover, the presence of soluble immune products (cytokines) and their receptors have been found in multiple nervous system and endocrine tissues (Besedovsky & del Rey, 1996). Alterations of nervous system function by exposure to a variety of stressors has been shown to result in dramatic changes in immune system function, and exposure to cytokines or various types of immune activation has been shown to significantly alter CNS function (Miller, In Press; McEwen, Biron, Brunson, Bulloch, Chambers, Dhabhar, Goldfarb, Kitson, Miller, Spencer, & Weiss, 1997; Kent, Bluthe, Kelley, & Dantzer, 1992). Given the vast potential for mutual regulation involving the immune system and the brain, there has been considerable interest in the possibility that immune system processes may be involved in the pathophysiology of psychiatric syndromes including major depression. One possible mechanism whereby the immune system might contribute to the development of pathology which manifests as depressive symptomatology involves the capacity of cytokines to inhibit functioning of the receptors for glucocorticoids, thus inducing a state of glucocorticoid resistance.