The target of selection matters: An established resistance-development-time negative genetic trade-off is not found when selecting on development time
The target of selection matters: An established resistance-development-time negative genetic trade-off is not found when selecting on development time
复制标题
选择的目标很重要：在选择发育时间时，未发现已建立的抗性-发育时间负遗传权衡
DOI：
10.1111/jeb.13639
复制
发表时间：
2020
影响因子：
2.1
通讯作者：
Bartlett L
中科院分区：
文献类型：
--
作者：
Bartlett L
权衡是进化结果的基础，在生态进化理论中起着核心作用。它们通常通过实验选择一种生活史特征，并在其他特征中寻找负相关来检验。例如，被选择抵抗病毒感染的间点蛾（mothPlodia interpunctella）种群显示出较长的发育时间带来的生活史成本。然而，我们很少检查这种负遗传相关性的检测是否取决于我们选择的性状。在这里，我们研究了在斑间蛾的发育时间和对病毒感染的抗性之间具有明显特征的负基因型权衡，并测试了对已知为抗性成本的表型的选择（更长的发育时间）是否导致预测的相关抗性增加。如果决定发育时间和抗性的基因之间存在紧密的多效性关系，那么当我们选择较长的发育时间时，我们可能会预期抗性会增加。然而，我们表明，与选择较短的开发时间相比，在该系统中选择较长的开发时间可以选择减少阻力。这表明典型的以权衡为特征的表型如何偏离这种权衡关系，并表明控制病毒抗性的基因与决定对关键生活史性状选择反应的基因之间几乎没有遗传联系。我们的结果对应用生物系统的选择策略和宿主-寄生虫相互作用的进化建模都很重要。摘要早闭的倍体对粒间倍体病毒的易感性明显低于晚闭的倍体。与其他研究相比，对病原体敏感性较低的选择是以后期封闭为代价的。
Trade‐offs are fundamental to evolutionary outcomes and play a central role in eco‐evolutionary theory. They are often examined by experimentally selecting on one life‐history trait and looking for negative correlations in other traits. For example, populations of the mothPlodia interpunctellaselected to resist viral infection show a life‐history cost with longer development times. However, we rarely examine whether the detection of such negative genetic correlations depends on the trait on which we select. Here, we examine a well‐characterized negative genotypic trade‐off between development time and resistance to viral infection in the mothPlodia interpunctellaand test whether selection on a phenotype known to be a cost of resistance (longer development time) leads to the predicted correlated increase in resistance. If there is tight pleiotropic relationship between genes that determine development time and resistance underpinning this trade‐off, we might expect increased resistance when we select on longer development time. However, we show that selecting for longer development time in this system selects for reduced resistance when compared to selection for shorter development time. This shows how phenotypes typically characterized by a trade‐off can deviate from that trade‐off relationship, and suggests little genetic linkage between the genes governing viral resistance and those that determine response to selection on the key life‐history trait. Our results are important for both selection strategies in applied biological systems and for evolutionary modelling of host–parasite interactions.AbstractPlodia selected for early eclosure show broadly lower susceptibility to Plodia interpunctella granulosis virus compared to Plodia selected for late eclosure. Contrast to other studies showing that selection for lower susceptibility to pathogens comes at the cost of later eclosure.