Cerebrospinal fluid probenecid studies: a reinterpretation.
Cerebrospinal fluid probenecid studies: a reinterpretation.
复制标题
脑脊液丙磺舒研究：重新解释。
作者：
R. Cowdry;M. Ebert;D. V. van Kammen;R. Post;F. Goodwin
丙磺舒用于阻断脑脊液（CSF）中酸性单胺代谢物的转运，假设CSF中代谢物浓度的升高将反映母体单胺的突触前“周转”。然而，丙磺舒的CSF水平与代谢物的CSF水平相关，表明在人体研究中获得的丙磺舒水平下，阻断不完全。本文回顾了有关CSF丙磺舒-代谢物相关性的文献，并提供了证明诊断组间相关性变化的数据。这些交叉诊断变化可能是由于膜转运特征的组间差异以及单胺代谢研究中“纠正”CSF丙磺舒浓度的混淆尝试。
Probenecid is used to block the transport of acid monoamine metabolites from cerebrospinal fluid (CSF), on the assumption that the resultant rise in CSF concentrations of the metabolites will reflect presynaptic "turnover" of the parent monoamine. However, CSF levels of probenecid correlate with CSF levels of the metabolite, suggesting that the blockade is incomplete at the probenecid levels obtained in human studies. This article reviews the literature on CSF probenecid-metabolite correlations and presents data demonstrating variations in the correlations across diagnostic groups. These cross-diagnostic variations may be due to group differences in membrane transport characteristics and and confound attempts to "correct for" CSF probenecid concentrations in studies of monoamine turnover.