Long noncoding RNAs in imprinting and X chromosome inactivation.
Long noncoding RNAs in imprinting and X chromosome inactivation.
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DOI：
10.3390/biom4010076
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发表时间：
2014-01-07
期刊：
影响因子：
5.5
通讯作者：
Carmichael GG
中科院分区：
文献类型：
--
作者：
Autuoro JM;Pirnie SP;Carmichael GG
近年来，长链非编码RNA （lncRNA）的研究进展迅速。技术进步和转录组的深度测序促进了许多新的lncrna的鉴定，其中许多具有不寻常的特性，然而，大多数这些分子的功能在很大程度上仍然是未知的。一些证据表明，这些lncrna中的一些可能通过将重塑因子募集到局部染色质上，以顺式和附近基因的方式调节自身的转录。值得注意的是，已知lncrna存在于许多印迹基因簇中。基因组印记是一个复杂和高度调控的过程，导致某些基因的单等位基因沉默，这是基于等位基因的父母起源。人们认为lncrna可能调控许多印迹基因座，然而，它们发挥这种影响的机制尚不清楚。本文将讨论主要印迹位点的lncrna的已知情况，以及它们在印迹调控中的作用。
The field of long noncoding RNA (lncRNA) research has been rapidly advancing in recent years. Technological advancements and deep-sequencing of the transcriptome have facilitated the identification of numerous new lncRNAs, many with unusual properties, however, the function of most of these molecules is still largely unknown. Some evidence suggests that several of these lncRNAs may regulate their own transcription in cis, and that of nearby genes, by recruiting remodeling factors to local chromatin. Notably, lncRNAs are known to exist at many imprinted gene clusters. Genomic imprinting is a complex and highly regulated process resulting in the monoallelic silencing of certain genes, based on the parent-of-origin of the allele. It is thought that lncRNAs may regulate many imprinted loci, however, the mechanism by which they exert such influence is poorly understood. This review will discuss what is known about the lncRNAs of major imprinted loci, and the roles they play in the regulation of imprinting.